Tardive dyskinesia and DRD2, DRD3, DRD4, 5-HT2A variants in schizophrenia: An association study with repeated assessment

Enrico Lattuada, Roberto Cavallaro, Alessandro Serretti, Cristina Lorenzi, Enrico Smeraldi

Research output: Contribution to journalArticle

Abstract

We performed an association study between four candidate genes, DRD2, DRD3, DRD4 and 5-HT2A for the presence of tardive dyskinesia (TD) on 84 patients with residual schizophrenia. The sample was evaluated again for the presence of TD after an interval of 3 years. The first group did not exhibit TD in either observation (n = 34) while in the second group of patients exhibited TD in at least one of the observations (n = 20 + 18). The clinical and socio-demographic characteristics were not significantly different between the two groups; the genetic analysis revealed a significant correlation between the C/C genotype of 5-HT2A and TD (p = 0.017). An association trend was observed between the 'short' variant of DRD4 and TD (p = 0.022). We did not observe any significant association for the DRD2 and DRD3 polymorphisms.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalInternational Journal of Neuropsychopharmacology
Volume7
Issue number4
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Dopamine receptor polymorphisms
  • Schizophrenia
  • Serotonin receptor polymorphisms
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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