Abstract
Using cells transformed by Rous sarcoma virus (RSV), an RNA tumor virus whose genetic and structural composition is fully known, the virus-induced surface antigens acting as targets for antibodies and complement were studied. Among the virus structural proteins, only the envelope antigen gp85, but not the core group-specific proteins or reverse transcriptase, were able to mediate immune lysis in the 51Cr-release assay. The group-specific antigenic determinants of gp85 were predominantly involved. The virus-induced cell surface antigen (VCSA), specific for transformation, was the only other molecule effective. Since different cells express either of these antigens, further support is given to the non-identity of virus structural antigens and VCSA.
| Original language | English |
|---|---|
| Pages (from-to) | 179-185 |
| Number of pages | 7 |
| Journal | Immunology |
| Volume | 39 |
| Issue number | 2 |
| Publication status | Published - 1980 |
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- Immunology
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Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts. / Prat, M.; Tato, F.; Tarone, G.; Comoglio, P. M.
In: Immunology, Vol. 39, No. 2, 1980, p. 179-185.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts
AU - Prat, M.
AU - Tato, F.
AU - Tarone, G.
AU - Comoglio, P. M.
PY - 1980
Y1 - 1980
N2 - Using cells transformed by Rous sarcoma virus (RSV), an RNA tumor virus whose genetic and structural composition is fully known, the virus-induced surface antigens acting as targets for antibodies and complement were studied. Among the virus structural proteins, only the envelope antigen gp85, but not the core group-specific proteins or reverse transcriptase, were able to mediate immune lysis in the 51Cr-release assay. The group-specific antigenic determinants of gp85 were predominantly involved. The virus-induced cell surface antigen (VCSA), specific for transformation, was the only other molecule effective. Since different cells express either of these antigens, further support is given to the non-identity of virus structural antigens and VCSA.
AB - Using cells transformed by Rous sarcoma virus (RSV), an RNA tumor virus whose genetic and structural composition is fully known, the virus-induced surface antigens acting as targets for antibodies and complement were studied. Among the virus structural proteins, only the envelope antigen gp85, but not the core group-specific proteins or reverse transcriptase, were able to mediate immune lysis in the 51Cr-release assay. The group-specific antigenic determinants of gp85 were predominantly involved. The virus-induced cell surface antigen (VCSA), specific for transformation, was the only other molecule effective. Since different cells express either of these antigens, further support is given to the non-identity of virus structural antigens and VCSA.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018848614&partnerID=8YFLogxK
M3 - Article
C2 - 6155325
AN - SCOPUS:0018848614
VL - 39
SP - 179
EP - 185
JO - Immunology
JF - Immunology
SN - 0019-2805
IS - 2
ER -