Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts

M. Prat, F. Tato, G. Tarone, P. M. Comoglio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Using cells transformed by Rous sarcoma virus (RSV), an RNA tumor virus whose genetic and structural composition is fully known, the virus-induced surface antigens acting as targets for antibodies and complement were studied. Among the virus structural proteins, only the envelope antigen gp85, but not the core group-specific proteins or reverse transcriptase, were able to mediate immune lysis in the 51Cr-release assay. The group-specific antigenic determinants of gp85 were predominantly involved. The virus-induced cell surface antigen (VCSA), specific for transformation, was the only other molecule effective. Since different cells express either of these antigens, further support is given to the non-identity of virus structural antigens and VCSA.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalImmunology
Volume39
Issue number2
Publication statusPublished - 1980

Fingerprint

Rous sarcoma virus
Surface Antigens
Fibroblasts
Viruses
Antigens
Antibodies
Viral Structural Proteins
RNA-Directed DNA Polymerase
Retroviridae
Epitopes
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Prat, M., Tato, F., Tarone, G., & Comoglio, P. M. (1980). Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts. Immunology, 39(2), 179-185.

Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts. / Prat, M.; Tato, F.; Tarone, G.; Comoglio, P. M.

In: Immunology, Vol. 39, No. 2, 1980, p. 179-185.

Research output: Contribution to journalArticle

Prat, M, Tato, F, Tarone, G & Comoglio, PM 1980, 'Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts', Immunology, vol. 39, no. 2, pp. 179-185.
Prat, M. ; Tato, F. ; Tarone, G. ; Comoglio, P. M. / Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts. In: Immunology. 1980 ; Vol. 39, No. 2. pp. 179-185.
@article{e07065b621e24c018546621c5191520f,
title = "Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts",
abstract = "Using cells transformed by Rous sarcoma virus (RSV), an RNA tumor virus whose genetic and structural composition is fully known, the virus-induced surface antigens acting as targets for antibodies and complement were studied. Among the virus structural proteins, only the envelope antigen gp85, but not the core group-specific proteins or reverse transcriptase, were able to mediate immune lysis in the 51Cr-release assay. The group-specific antigenic determinants of gp85 were predominantly involved. The virus-induced cell surface antigen (VCSA), specific for transformation, was the only other molecule effective. Since different cells express either of these antigens, further support is given to the non-identity of virus structural antigens and VCSA.",
author = "M. Prat and F. Tato and G. Tarone and Comoglio, {P. M.}",
year = "1980",
language = "English",
volume = "39",
pages = "179--185",
journal = "Immunology",
issn = "0019-2805",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts

AU - Prat, M.

AU - Tato, F.

AU - Tarone, G.

AU - Comoglio, P. M.

PY - 1980

Y1 - 1980

N2 - Using cells transformed by Rous sarcoma virus (RSV), an RNA tumor virus whose genetic and structural composition is fully known, the virus-induced surface antigens acting as targets for antibodies and complement were studied. Among the virus structural proteins, only the envelope antigen gp85, but not the core group-specific proteins or reverse transcriptase, were able to mediate immune lysis in the 51Cr-release assay. The group-specific antigenic determinants of gp85 were predominantly involved. The virus-induced cell surface antigen (VCSA), specific for transformation, was the only other molecule effective. Since different cells express either of these antigens, further support is given to the non-identity of virus structural antigens and VCSA.

AB - Using cells transformed by Rous sarcoma virus (RSV), an RNA tumor virus whose genetic and structural composition is fully known, the virus-induced surface antigens acting as targets for antibodies and complement were studied. Among the virus structural proteins, only the envelope antigen gp85, but not the core group-specific proteins or reverse transcriptase, were able to mediate immune lysis in the 51Cr-release assay. The group-specific antigenic determinants of gp85 were predominantly involved. The virus-induced cell surface antigen (VCSA), specific for transformation, was the only other molecule effective. Since different cells express either of these antigens, further support is given to the non-identity of virus structural antigens and VCSA.

UR - http://www.scopus.com/inward/record.url?scp=0018848614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018848614&partnerID=8YFLogxK

M3 - Article

C2 - 6155325

AN - SCOPUS:0018848614

VL - 39

SP - 179

EP - 185

JO - Immunology

JF - Immunology

SN - 0019-2805

IS - 2

ER -