Abstract
Using cells transformed by Rous sarcoma virus (RSV), an RNA tumor virus whose genetic and structural composition is fully known, the virus-induced surface antigens acting as targets for antibodies and complement were studied. Among the virus structural proteins, only the envelope antigen gp85, but not the core group-specific proteins or reverse transcriptase, were able to mediate immune lysis in the 51Cr-release assay. The group-specific antigenic determinants of gp85 were predominantly involved. The virus-induced cell surface antigen (VCSA), specific for transformation, was the only other molecule effective. Since different cells express either of these antigens, further support is given to the non-identity of virus structural antigens and VCSA.
Original language | English |
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Pages (from-to) | 179-185 |
Number of pages | 7 |
Journal | Immunology |
Volume | 39 |
Issue number | 2 |
Publication status | Published - 1980 |
ASJC Scopus subject areas
- Immunology