Target-controlled propofol infusion during monitored anesthesia in patients undergoing ERCP

Lorella Fanti, Massimo Agostoni, Andrea Casati, Mario Guslandi, Patrizia Giollo, Giorgio Torri, Pier Alberto Testoni

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Background A target-controlled infusion system automatically adjusts the rate of infusion of propofol to maintain a desired (target) concentration. The aim of this study was to determine whether administration of propofol with a target-controlled infusion system could improve the sedation of patients undergoing ERCP. Methods A total of 205 consecutive patients undergoing ERCP were sedated by using a propofol target-controlled infusion system by an anesthesiologist. The target plasma concentration of propofol ranged from 2 to 5 μg/mL. A bolus dose of fentanyl (50-100 mcg) was administered if signs of insufficient analgesia were observed at the maximum target concentration of propofol allowed. The technical difficulty of ERCP was graded on a scale from 1 (least difficult) to 5 (most difficult). Results The mean dosages of propofol and fentanyl administered were 465 (245) mg and 59 (23) mcg, respectively. The total dose of propofol administered and the mean duration of ERCP were related to the degree of difficulty of the procedure. No severe complication was observed; mean time to discharge was 31 (12) minutes. Time to discharge was not influenced by the difficulty of ERCP or by the total dose of propofol administered. Conclusions A target-controlled infusion system for administration of propofol provides safe and effective sedation during ERCP. Further studies are needed to determine the cost-effectiveness and the safety profile for infusion of propofol with a target-controlled infusion system by a nonanesthesiologist during ERCP.

Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalGastrointestinal Endoscopy
Volume60
Issue number3
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Endoscopic Retrograde Cholangiopancreatography
Propofol
Anesthesia
Fentanyl
Analgesia
Cost-Benefit Analysis
Safety

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Target-controlled propofol infusion during monitored anesthesia in patients undergoing ERCP. / Fanti, Lorella; Agostoni, Massimo; Casati, Andrea; Guslandi, Mario; Giollo, Patrizia; Torri, Giorgio; Alberto Testoni, Pier.

In: Gastrointestinal Endoscopy, Vol. 60, No. 3, 09.2004, p. 361-366.

Research output: Contribution to journalArticle

Fanti, Lorella ; Agostoni, Massimo ; Casati, Andrea ; Guslandi, Mario ; Giollo, Patrizia ; Torri, Giorgio ; Alberto Testoni, Pier. / Target-controlled propofol infusion during monitored anesthesia in patients undergoing ERCP. In: Gastrointestinal Endoscopy. 2004 ; Vol. 60, No. 3. pp. 361-366.
@article{37e149588596431c806ab60830ee151b,
title = "Target-controlled propofol infusion during monitored anesthesia in patients undergoing ERCP",
abstract = "Background A target-controlled infusion system automatically adjusts the rate of infusion of propofol to maintain a desired (target) concentration. The aim of this study was to determine whether administration of propofol with a target-controlled infusion system could improve the sedation of patients undergoing ERCP. Methods A total of 205 consecutive patients undergoing ERCP were sedated by using a propofol target-controlled infusion system by an anesthesiologist. The target plasma concentration of propofol ranged from 2 to 5 μg/mL. A bolus dose of fentanyl (50-100 mcg) was administered if signs of insufficient analgesia were observed at the maximum target concentration of propofol allowed. The technical difficulty of ERCP was graded on a scale from 1 (least difficult) to 5 (most difficult). Results The mean dosages of propofol and fentanyl administered were 465 (245) mg and 59 (23) mcg, respectively. The total dose of propofol administered and the mean duration of ERCP were related to the degree of difficulty of the procedure. No severe complication was observed; mean time to discharge was 31 (12) minutes. Time to discharge was not influenced by the difficulty of ERCP or by the total dose of propofol administered. Conclusions A target-controlled infusion system for administration of propofol provides safe and effective sedation during ERCP. Further studies are needed to determine the cost-effectiveness and the safety profile for infusion of propofol with a target-controlled infusion system by a nonanesthesiologist during ERCP.",
author = "Lorella Fanti and Massimo Agostoni and Andrea Casati and Mario Guslandi and Patrizia Giollo and Giorgio Torri and {Alberto Testoni}, Pier",
year = "2004",
month = "9",
doi = "10.1016/S0016-5107(04)01713-4",
language = "English",
volume = "60",
pages = "361--366",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Target-controlled propofol infusion during monitored anesthesia in patients undergoing ERCP

AU - Fanti, Lorella

AU - Agostoni, Massimo

AU - Casati, Andrea

AU - Guslandi, Mario

AU - Giollo, Patrizia

AU - Torri, Giorgio

AU - Alberto Testoni, Pier

PY - 2004/9

Y1 - 2004/9

N2 - Background A target-controlled infusion system automatically adjusts the rate of infusion of propofol to maintain a desired (target) concentration. The aim of this study was to determine whether administration of propofol with a target-controlled infusion system could improve the sedation of patients undergoing ERCP. Methods A total of 205 consecutive patients undergoing ERCP were sedated by using a propofol target-controlled infusion system by an anesthesiologist. The target plasma concentration of propofol ranged from 2 to 5 μg/mL. A bolus dose of fentanyl (50-100 mcg) was administered if signs of insufficient analgesia were observed at the maximum target concentration of propofol allowed. The technical difficulty of ERCP was graded on a scale from 1 (least difficult) to 5 (most difficult). Results The mean dosages of propofol and fentanyl administered were 465 (245) mg and 59 (23) mcg, respectively. The total dose of propofol administered and the mean duration of ERCP were related to the degree of difficulty of the procedure. No severe complication was observed; mean time to discharge was 31 (12) minutes. Time to discharge was not influenced by the difficulty of ERCP or by the total dose of propofol administered. Conclusions A target-controlled infusion system for administration of propofol provides safe and effective sedation during ERCP. Further studies are needed to determine the cost-effectiveness and the safety profile for infusion of propofol with a target-controlled infusion system by a nonanesthesiologist during ERCP.

AB - Background A target-controlled infusion system automatically adjusts the rate of infusion of propofol to maintain a desired (target) concentration. The aim of this study was to determine whether administration of propofol with a target-controlled infusion system could improve the sedation of patients undergoing ERCP. Methods A total of 205 consecutive patients undergoing ERCP were sedated by using a propofol target-controlled infusion system by an anesthesiologist. The target plasma concentration of propofol ranged from 2 to 5 μg/mL. A bolus dose of fentanyl (50-100 mcg) was administered if signs of insufficient analgesia were observed at the maximum target concentration of propofol allowed. The technical difficulty of ERCP was graded on a scale from 1 (least difficult) to 5 (most difficult). Results The mean dosages of propofol and fentanyl administered were 465 (245) mg and 59 (23) mcg, respectively. The total dose of propofol administered and the mean duration of ERCP were related to the degree of difficulty of the procedure. No severe complication was observed; mean time to discharge was 31 (12) minutes. Time to discharge was not influenced by the difficulty of ERCP or by the total dose of propofol administered. Conclusions A target-controlled infusion system for administration of propofol provides safe and effective sedation during ERCP. Further studies are needed to determine the cost-effectiveness and the safety profile for infusion of propofol with a target-controlled infusion system by a nonanesthesiologist during ERCP.

UR - http://www.scopus.com/inward/record.url?scp=4444279868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444279868&partnerID=8YFLogxK

U2 - 10.1016/S0016-5107(04)01713-4

DO - 10.1016/S0016-5107(04)01713-4

M3 - Article

C2 - 15332024

AN - SCOPUS:4444279868

VL - 60

SP - 361

EP - 366

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

IS - 3

ER -