Target therapy in elderly breast cancer patients

Paolo Carli, Elisa Turchet, Daniela Quitadamo, Antonella Spada, Gianmaria Miolo, Elda Lamaj, Simon Spazzapan, Vincenzo Di Lauro, Riccardo Dolcetti, Andrea Veronesi, Diana Crivellari

Research output: Contribution to journalArticlepeer-review

Abstract

Substantial progress has been made in the management of breast cancer by targeting HER2 and VEGF pathways. Although the efficacy and safety of target therapy in breast cancer have been established, no specific phase III trial has addressed these issues in the elderly population and the only data available derive from subanalyses or retrospective series. The aim of this review is to summarize the available evidence in this special population and to encourage further well designed studies in elderly breast cancer patients.

Original languageEnglish
Pages (from-to)422-431
Number of pages10
JournalCritical Reviews in Oncology/Hematology
Volume83
Issue number3
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Bevacizumab
  • Breast cancer
  • Elderly
  • Lapatinib
  • Trastuzumab

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

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