Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study

L. Strigari, V. Ferrero, G. Visona, F. Dalmasso, A. Gobbato, P. Cerello, S. Visentin, A. Attili

Research output: Contribution to journalArticle

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Abstract

PURPOSE: In recent years, there has been growing interest in the use of gold nanoparticles (GNPs) combined with radiotherapy to improve tumor control. However, the complex interplay between GNP uptake and dose distribution in realistic clinical treatment are still somewhat unknown. METHODS: The effects of different concentrations of 2 nm diameter GNP, ranging from 0 to 5x105 nanoparticles per tumoral cell, were theoretically investigated. A parametrization of the GNP distribution outside the target was carried out using a Gaussian standard deviation sigma, from a zero value, relative to a selective concentration of GNPs inside the tumor volume alone, to 50mm, when GNPs are spatially distributed also in the healthy tissues surrounding the tumor. Treatment simulations of five patients with breast cancer were performed with 6 and 15 MV photons assuming a partial breast irradiation. A closed analytical reformulation of the Local Effect Model coupled with the estimation of local dose deposited around a GNP was validated using an in vitro study for MDA-MB-231 tumoral cells. The expected treatment outcome was quantified in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP) as a function of the spatially varying gold uptake. RESULTS: Breast cancer treatment planning simulations show improved treatment outcomes when GNPs are selectively concentrated in the tumor volume (i.e., sigma = 0 mm). In particular, the TCP increases up to 18% for 5x105 nanoparticles per cell in the tumor region depending on the treatment schedules, whereas an improvement of the therapeutic index is observed only for concentrations of about 105 GNPs per tumoral cell and limited spatial distribution in the normal tissue. CONCLUSIONS: The model provides a useful framework to estimate the nanoparticle-driven radiosensitivity in breast cancer treatment irradiation, accounting for the complex interplay between dose and GNP uptake distributions.
Original languageEnglish
Pages (from-to)1993-2001
Number of pages9
JournalMedical Physics
Volume44
Issue number5
DOIs
Publication statusPublished - 2017

Fingerprint

Gold
Nanoparticles
Radiotherapy
Breast Neoplasms
Therapeutics
Neoplasms
Tumor Burden
Patient Simulation
Radiation Tolerance
Normal Distribution
Photons
Appointments and Schedules
Breast

Keywords

  • breast cancer
  • gold nanoparticles
  • radiosensitization
  • radiotherapy
  • treatment planning

Cite this

Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study. / Strigari, L.; Ferrero, V.; Visona, G.; Dalmasso, F.; Gobbato, A.; Cerello, P.; Visentin, S.; Attili, A.

In: Medical Physics, Vol. 44, No. 5, 2017, p. 1993-2001.

Research output: Contribution to journalArticle

Strigari, L, Ferrero, V, Visona, G, Dalmasso, F, Gobbato, A, Cerello, P, Visentin, S & Attili, A 2017, 'Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study', Medical Physics, vol. 44, no. 5, pp. 1993-2001. https://doi.org/10.1002/mp.12178 [doi]
Strigari, L. ; Ferrero, V. ; Visona, G. ; Dalmasso, F. ; Gobbato, A. ; Cerello, P. ; Visentin, S. ; Attili, A. / Targeted dose enhancement in radiotherapy for breast cancer using gold nanoparticles, part 2: A treatment planning study. In: Medical Physics. 2017 ; Vol. 44, No. 5. pp. 1993-2001.
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AU - Strigari, L.

AU - Ferrero, V.

AU - Visona, G.

AU - Dalmasso, F.

AU - Gobbato, A.

AU - Cerello, P.

AU - Visentin, S.

AU - Attili, A.

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N2 - PURPOSE: In recent years, there has been growing interest in the use of gold nanoparticles (GNPs) combined with radiotherapy to improve tumor control. However, the complex interplay between GNP uptake and dose distribution in realistic clinical treatment are still somewhat unknown. METHODS: The effects of different concentrations of 2 nm diameter GNP, ranging from 0 to 5x105 nanoparticles per tumoral cell, were theoretically investigated. A parametrization of the GNP distribution outside the target was carried out using a Gaussian standard deviation sigma, from a zero value, relative to a selective concentration of GNPs inside the tumor volume alone, to 50mm, when GNPs are spatially distributed also in the healthy tissues surrounding the tumor. Treatment simulations of five patients with breast cancer were performed with 6 and 15 MV photons assuming a partial breast irradiation. A closed analytical reformulation of the Local Effect Model coupled with the estimation of local dose deposited around a GNP was validated using an in vitro study for MDA-MB-231 tumoral cells. The expected treatment outcome was quantified in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP) as a function of the spatially varying gold uptake. RESULTS: Breast cancer treatment planning simulations show improved treatment outcomes when GNPs are selectively concentrated in the tumor volume (i.e., sigma = 0 mm). In particular, the TCP increases up to 18% for 5x105 nanoparticles per cell in the tumor region depending on the treatment schedules, whereas an improvement of the therapeutic index is observed only for concentrations of about 105 GNPs per tumoral cell and limited spatial distribution in the normal tissue. CONCLUSIONS: The model provides a useful framework to estimate the nanoparticle-driven radiosensitivity in breast cancer treatment irradiation, accounting for the complex interplay between dose and GNP uptake distributions.

AB - PURPOSE: In recent years, there has been growing interest in the use of gold nanoparticles (GNPs) combined with radiotherapy to improve tumor control. However, the complex interplay between GNP uptake and dose distribution in realistic clinical treatment are still somewhat unknown. METHODS: The effects of different concentrations of 2 nm diameter GNP, ranging from 0 to 5x105 nanoparticles per tumoral cell, were theoretically investigated. A parametrization of the GNP distribution outside the target was carried out using a Gaussian standard deviation sigma, from a zero value, relative to a selective concentration of GNPs inside the tumor volume alone, to 50mm, when GNPs are spatially distributed also in the healthy tissues surrounding the tumor. Treatment simulations of five patients with breast cancer were performed with 6 and 15 MV photons assuming a partial breast irradiation. A closed analytical reformulation of the Local Effect Model coupled with the estimation of local dose deposited around a GNP was validated using an in vitro study for MDA-MB-231 tumoral cells. The expected treatment outcome was quantified in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP) as a function of the spatially varying gold uptake. RESULTS: Breast cancer treatment planning simulations show improved treatment outcomes when GNPs are selectively concentrated in the tumor volume (i.e., sigma = 0 mm). In particular, the TCP increases up to 18% for 5x105 nanoparticles per cell in the tumor region depending on the treatment schedules, whereas an improvement of the therapeutic index is observed only for concentrations of about 105 GNPs per tumoral cell and limited spatial distribution in the normal tissue. CONCLUSIONS: The model provides a useful framework to estimate the nanoparticle-driven radiosensitivity in breast cancer treatment irradiation, accounting for the complex interplay between dose and GNP uptake distributions.

KW - breast cancer

KW - gold nanoparticles

KW - radiosensitization

KW - radiotherapy

KW - treatment planning

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JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

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ER -