Targeted drug delivery and penetration into solid tumors

Angelo Corti, Fabio Pastorino, Flavio Curnis, Wadih Arap, Mirco Ponzoni, Renata Pasqualini

Research output: Contribution to journalArticle

Abstract

Delivery and penetration of chemotherapeutic drugs into tumors are limited by a number of factors related to abnormal vasculature and altered stroma composition in neoplastic tissues. Coupling of chemotherapeutic drugs with tumor vasculature-homing peptides or administration of drugs in combination with biological agents that affect the integrity of the endothelial lining of tumor vasculature is an appealing strategy to improve drug delivery to tumor cells. Promising approaches to achieve this goal are based on the use of Asn-Gly-Arg (NGR)-containing peptides as ligands for drug delivery and of NGR-TNF, a peptide-tumor necrosis factor-α fusion protein that selectively alters drug penetration barriers and that is currently tested in a randomized Phase III trial in patients with malignant pleural mesothelioma.

Original languageEnglish
Pages (from-to)1078-1091
Number of pages14
JournalMedicinal Research Reviews
Volume32
Issue number5
DOIs
Publication statusPublished - Sep 2012

Keywords

  • αvβ3 integrin
  • CD13
  • Chemotherapy
  • Doxorubicin
  • IsoDGR
  • Liposomes
  • NGR
  • NGR-hTNF
  • NGR-TNF
  • Vascular targeting

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Pharmacology

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