Targeted therapies in advanced renal cell carcinoma: The role of metastatic sites as a prognostic factor

Paolo Grassi, Elena Verzoni, Luca Porcu, Isabella Testa, Roberto Iacovelli, Valter Torri, Filippo De Braud, Giuseppe Procopio

Research output: Contribution to journalArticle

Abstract

Aim: This retrospective study evaluates whether metastatic sites were associated with progression-free survival (PFS) and overall survival (OS) in patients with renal cell carcinoma treated with targeted therapies. Patients & methods: In total, 358 patients were analyzed. Results & conclusion: After a median follow-up of 56.1 months, median PFS was 11 months and median OS was 24.2 months. Metastatic sites were associated with PFS: lymph nodes (HR: 1.43; 95% CI: 1.12-1.83; p = 0.004), liver (HR: 1.41; 95% CI: 1.05-1.90; p = 0.021), bone (HR: 1.26; 95% CI: 0.96-1.65; p = 0.091), brain (HR: 0.81; 95% CI: 0.46-1.43; p = 0.474) and other sites (HR: 1.07; 95% CI: 0.83-1.38; p = 0.589). Metastatic sites were associated with OS: lymph nodes (HR: 1.73; 95% CI: 1.31-2.29; p <0.001), liver (HR: 1.71; 95% CI: 1.23-2.37; p = 0.002), bone (HR: 1.48; 95% CI: 1.10-1.98; p = 0.009), brain (HR: 1.21; 95% CI: 0.64-2.28; p = 0.568) and other sites (HR: 1.09; 95% CI: 0.81-1.47; p = 0.568). Patients with >2 metastatic sites had shorter PFS and OS. Every association was lost when introducing the Motzer score in regression models.

Original languageEnglish
Pages (from-to)1361-1372
Number of pages12
JournalFuture Oncology
Volume10
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • metastasis
  • prognostic factors
  • renal cell carcinoma
  • targeted therapies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

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