Targeting 5-lipoxygenase signaling pathways to reverse drug resistance in cancer

Alfonso Catalano, Antonio Procopio

Research output: Contribution to journalArticlepeer-review

Abstract

5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalLetters in Drug Design and Discovery
Volume3
Issue number7
DOIs
Publication statusPublished - 2006

Keywords

  • 5-lipoxygenase
  • Cancer therapy
  • Eicosanoids
  • Lipoxygenase inhibitors

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine

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