Targeting 5-lipoxygenase signaling pathways to reverse drug resistance in cancer

Alfonso Catalano; Antonio Procopio

doi:10.2174/157018006778194817

Targeting 5-lipoxygenase signaling pathways to reverse drug resistance in cancer

Alfonso Catalano, Antonio Procopio

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.

Original language	English
Pages (from-to)	459-461
Number of pages	3
Journal	Letters in Drug Design and Discovery
Volume	3
Issue number	7
DOIs	https://doi.org/10.2174/157018006778194817
Publication status	Published - 2006

Keywords

5-lipoxygenase
Cancer therapy
Eicosanoids
Lipoxygenase inhibitors

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Molecular Medicine

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10.2174/157018006778194817

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abstract = "5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.",

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AB - 5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.

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KW - Eicosanoids

KW - Lipoxygenase inhibitors

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Targeting 5-lipoxygenase signaling pathways to reverse drug resistance in cancer

Abstract

Keywords

ASJC Scopus subject areas

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