TY - JOUR
T1 - Targeting angiogenesis with compounds from the extracellular matrix
AU - Belotti, Dorina
AU - Foglieni, Chiara
AU - Resovi, Andrea
AU - Giavazzi, Raffaella
AU - Taraboletti, Giulia
PY - 2011/12
Y1 - 2011/12
N2 - The extracellular matrix (ECM) is the central element of a pericellular network of bioactive molecules. It orchestrates molecular interactions, availability and activity, acting as a key regulator of cell functions and complex biological processes, including physiological and pathological angiogenesis. The ECM serves as a source of both stimulatory and inhibitory angiogenesis regulatory factors. The observation that several endogenous inhibitors of angiogenesis derive from the ECM proves its importance in physiological angiogenesis, and point to the ECM as a precious source of therapeutic agents for angiogenesis-driven diseases, including cancer growth and metastatic dissemination. This review focuses on the different approaches to exploit ECM molecules for designing tools for therapeutic inhibition or monitoring of pathological angiogenesis, with particular focus on antineoplastic therapy, and emphasis on peptides of ECM moieties and mimetic small molecules.
AB - The extracellular matrix (ECM) is the central element of a pericellular network of bioactive molecules. It orchestrates molecular interactions, availability and activity, acting as a key regulator of cell functions and complex biological processes, including physiological and pathological angiogenesis. The ECM serves as a source of both stimulatory and inhibitory angiogenesis regulatory factors. The observation that several endogenous inhibitors of angiogenesis derive from the ECM proves its importance in physiological angiogenesis, and point to the ECM as a precious source of therapeutic agents for angiogenesis-driven diseases, including cancer growth and metastatic dissemination. This review focuses on the different approaches to exploit ECM molecules for designing tools for therapeutic inhibition or monitoring of pathological angiogenesis, with particular focus on antineoplastic therapy, and emphasis on peptides of ECM moieties and mimetic small molecules.
KW - Extracellular matrix
KW - Inhibitors of angiogenesis
KW - Mimetic small molecules
KW - Peptides
KW - Proteolytic fragments
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U2 - 10.1016/j.biocel.2011.08.012
DO - 10.1016/j.biocel.2011.08.012
M3 - Article
C2 - 21864705
AN - SCOPUS:80255123709
VL - 43
SP - 1674
EP - 1685
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
SN - 1357-2725
IS - 12
ER -