Targeting bone metastases: New drugs for new targets

Francesco Pantano, Alice Zoccoli, Michele Iuliani, Marco Fioramonti, Gaetano Lanzetta, Giuseppe Tonini, Daniele Santini

Research output: Contribution to journalArticlepeer-review


Bone metastases development requires multistep and multicellular machinery consisting not only of processes shared with any types of metastases (formation of a pre-metastatic niche, chemotaxis of tumor cells into the host tissue, tumor cells escape from the microvasculature), but also biological interactions that are strictly related to bone microenvironment (bone marrow colonization by cancer cells, osteomimicry, deregulation of bone homeostasis). The aim of this review is to depict the complex sequence of events from early cancer cells dissemination to the onset of clinically detectable bone lesions with particular attention to those molecular targets that have been investigated in order to find out new therapeutical approaches helpful in reducing clinical sequelae of skeletal metastases.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalClinical Reviews in Bone and Mineral Metabolism
Issue number3-4
Publication statusPublished - Dec 2013


  • Bone metastases
  • Bone microenvironment
  • Osteomimicry
  • Target therapy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


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