Targeting chemokines in cancer

Research output: Contribution to journalArticle

Abstract

The chemokine system is now recognized as a key element in cancer-related inflammation because it can affect tumor progression acting on tumor-stroma and also directly on tumor cells. Chemokines are produced by both tumor cells and the tumor microenvironment and modulate not only leukocyte infiltration and angiogenesis but also senescence, cell survival and metastasis. Here, we review available information in preclinical and clinical settings that suggest that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.

Original languageEnglish
Pages (from-to)161-169
Number of pages9
JournalCurrent Immunology Reviews
Volume8
Issue number2
DOIs
Publication statusPublished - May 2012

Keywords

  • Cancer
  • Chemokine
  • Chemokine receptor
  • Inflammation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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