Abstract
Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.
| Original language | English |
|---|---|
| Pages (from-to) | 104317 |
| Journal | Pharmacological Research |
| Volume | 146 |
| DOIs | |
| Publication status | E-pub ahead of print - Jun 17 2019 |
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Targeting Drp1 and mitochondrial fission for therapeutic immune modulation. / Simula, Luca; Campanella, Michelangelo; Campello, Silvia.
In: Pharmacological Research, Vol. 146, 17.06.2019, p. 104317.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Targeting Drp1 and mitochondrial fission for therapeutic immune modulation
AU - Simula, Luca
AU - Campanella, Michelangelo
AU - Campello, Silvia
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019/6/17
Y1 - 2019/6/17
N2 - Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.
AB - Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.
U2 - 10.1016/j.phrs.2019.104317
DO - 10.1016/j.phrs.2019.104317
M3 - Review article
C2 - 31220561
VL - 146
SP - 104317
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
ER -