Targeting Drp1 and mitochondrial fission for therapeutic immune modulation

Research output: Contribution to journalReview article

Abstract

Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.

Original languageEnglish
Pages (from-to)104317
JournalPharmacological Research
Volume146
DOIs
Publication statusE-pub ahead of print - Jun 17 2019

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Mitochondrial Dynamics
T-Lymphocytes
Mitochondria
Therapeutics
Proteins
Organelles
Cell Movement
Cell Differentiation
Pharmacology

Cite this

@article{9e8ee2c738d944f48963945d045221bc,
title = "Targeting Drp1 and mitochondrial fission for therapeutic immune modulation",
abstract = "Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.",
author = "Luca Simula and Michelangelo Campanella and Silvia Campello",
note = "Copyright {\circledC} 2019 Elsevier Ltd. All rights reserved.",
year = "2019",
month = "6",
day = "17",
doi = "10.1016/j.phrs.2019.104317",
language = "English",
volume = "146",
pages = "104317",
journal = "Pharmacological Research",
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TY - JOUR

T1 - Targeting Drp1 and mitochondrial fission for therapeutic immune modulation

AU - Simula, Luca

AU - Campanella, Michelangelo

AU - Campello, Silvia

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2019/6/17

Y1 - 2019/6/17

N2 - Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.

AB - Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.

U2 - 10.1016/j.phrs.2019.104317

DO - 10.1016/j.phrs.2019.104317

M3 - Review article

C2 - 31220561

VL - 146

SP - 104317

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

ER -