Targeting hypoxia in tumor: a new promising therapeutic strategy

Research output: Contribution to journalEditorial

Abstract

Low oxygen condition (hypoxia) is considered a hallmark of rapidly growing solid tumors. The presence of hypoxia renders tumor cells resistant to conventional chemo- and radio-therapy selecting a more malignant and invasive phenotype, and playing a negative role in patient prognosis. This commentary wishes to recognize the 2019 Nobel Prize in Medicine awarded to three physicians-scientists, Prof. William G. Kaelin Jr., Prof. Sir Peter J. Ratcliffe, and Prof. Gregg L. Semenza, for their discovery of the mechanisms mediating cell ability to sense and adapt to changes in oxygen availability. Their studies established the basis for our understanding of the role of hypoxia in a variety of diseases, including anemia, renal failure, cardiovascular disease, metabolic diseases, and cancer, paving the way for new promising therapeutic strategies through the development of drugs that can either activate or block the oxygen-sensing machinery.

Original languageEnglish
Number of pages1
JournalJournal of experimental & clinical cancer research : CR
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 10 2020

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Oxygen
Nobel Prize
Metabolic Diseases
Radio
Renal Insufficiency
Anemia
Neoplasms
Cardiovascular Diseases
Therapeutics
Medicine
Physicians
Phenotype
Pharmaceutical Preparations
Tumor Hypoxia
Hypoxia

Keywords

  • Angiogenesis
  • Cancer
  • HIF
  • Hypoxia
  • Metastasis
  • Oxygen sensing
  • VEGF
  • VHL

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "Targeting hypoxia in tumor: a new promising therapeutic strategy",
abstract = "Low oxygen condition (hypoxia) is considered a hallmark of rapidly growing solid tumors. The presence of hypoxia renders tumor cells resistant to conventional chemo- and radio-therapy selecting a more malignant and invasive phenotype, and playing a negative role in patient prognosis. This commentary wishes to recognize the 2019 Nobel Prize in Medicine awarded to three physicians-scientists, Prof. William G. Kaelin Jr., Prof. Sir Peter J. Ratcliffe, and Prof. Gregg L. Semenza, for their discovery of the mechanisms mediating cell ability to sense and adapt to changes in oxygen availability. Their studies established the basis for our understanding of the role of hypoxia in a variety of diseases, including anemia, renal failure, cardiovascular disease, metabolic diseases, and cancer, paving the way for new promising therapeutic strategies through the development of drugs that can either activate or block the oxygen-sensing machinery.",
keywords = "Angiogenesis, Cancer, HIF, Hypoxia, Metastasis, Oxygen sensing, VEGF, VHL",
author = "Bosco, {Maria Carla} and Gabriella D'Orazi and {Del Bufalo}, Donatella",
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T1 - Targeting hypoxia in tumor

T2 - a new promising therapeutic strategy

AU - Bosco, Maria Carla

AU - D'Orazi, Gabriella

AU - Del Bufalo, Donatella

PY - 2020/1/10

Y1 - 2020/1/10

N2 - Low oxygen condition (hypoxia) is considered a hallmark of rapidly growing solid tumors. The presence of hypoxia renders tumor cells resistant to conventional chemo- and radio-therapy selecting a more malignant and invasive phenotype, and playing a negative role in patient prognosis. This commentary wishes to recognize the 2019 Nobel Prize in Medicine awarded to three physicians-scientists, Prof. William G. Kaelin Jr., Prof. Sir Peter J. Ratcliffe, and Prof. Gregg L. Semenza, for their discovery of the mechanisms mediating cell ability to sense and adapt to changes in oxygen availability. Their studies established the basis for our understanding of the role of hypoxia in a variety of diseases, including anemia, renal failure, cardiovascular disease, metabolic diseases, and cancer, paving the way for new promising therapeutic strategies through the development of drugs that can either activate or block the oxygen-sensing machinery.

AB - Low oxygen condition (hypoxia) is considered a hallmark of rapidly growing solid tumors. The presence of hypoxia renders tumor cells resistant to conventional chemo- and radio-therapy selecting a more malignant and invasive phenotype, and playing a negative role in patient prognosis. This commentary wishes to recognize the 2019 Nobel Prize in Medicine awarded to three physicians-scientists, Prof. William G. Kaelin Jr., Prof. Sir Peter J. Ratcliffe, and Prof. Gregg L. Semenza, for their discovery of the mechanisms mediating cell ability to sense and adapt to changes in oxygen availability. Their studies established the basis for our understanding of the role of hypoxia in a variety of diseases, including anemia, renal failure, cardiovascular disease, metabolic diseases, and cancer, paving the way for new promising therapeutic strategies through the development of drugs that can either activate or block the oxygen-sensing machinery.

KW - Angiogenesis

KW - Cancer

KW - HIF

KW - Hypoxia

KW - Metastasis

KW - Oxygen sensing

KW - VEGF

KW - VHL

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