Targeting inflammation to slow or delay functional decline: Where are we?

Andrea Corsonello, Sabrina Garasto, Angela Marie Abbatecola, Giuseppina Rose, Giuseppe Passarino, Bruno Mazzei, Luigi Pranno, Enrico Eugenio Guffanti, Silvia Bustacchini, Fabrizia Lattanzio

Research output: Contribution to journalArticlepeer-review


The role of inflammation in the pathophysiology of chronic age-related diseases is increasingly recognized, and inflammation could represent the common pathway linking diseases and disability. Thus, targeting inflammation could represent a useful strategy at preventing or delaying functional decline. In this paper we review recent evidence suggesting that selected drugs, such as statins, fibrates, angiotensin converting enzyme-inhibitors and angiotensin receptor blockers, and physical exercise may be able to contrast functional decline by blunting inflammation. Results from randomized trials investigating the effects of physical activity programs on inflammation and functional decline is still limited, and further investigations are warranted.

Original languageEnglish
Pages (from-to)603-614
Number of pages12
Issue number5
Publication statusPublished - Oct 2010


  • Aging
  • Angiotensin receptor blockers
  • Angiotensin-converting enzyme-inhibitors
  • Chronic diseases
  • Functional decline
  • Inflammation
  • Physical exercise
  • Statins

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Ageing


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