Targeting inflammation to slow or delay functional decline: Where are we?

Andrea Corsonello, Sabrina Garasto, Angela Marie Abbatecola, Giuseppina Rose, Giuseppe Passarino, Bruno Mazzei, Luigi Pranno, Enrico Eugenio Guffanti, Silvia Bustacchini, Fabrizia Lattanzio

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The role of inflammation in the pathophysiology of chronic age-related diseases is increasingly recognized, and inflammation could represent the common pathway linking diseases and disability. Thus, targeting inflammation could represent a useful strategy at preventing or delaying functional decline. In this paper we review recent evidence suggesting that selected drugs, such as statins, fibrates, angiotensin converting enzyme-inhibitors and angiotensin receptor blockers, and physical exercise may be able to contrast functional decline by blunting inflammation. Results from randomized trials investigating the effects of physical activity programs on inflammation and functional decline is still limited, and further investigations are warranted.

Original languageEnglish
Pages (from-to)603-614
Number of pages12
JournalBiogerontology
Volume11
Issue number5
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Inflammation
Fibric Acids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Exercise
Pharmaceutical Preparations

Keywords

  • Aging
  • Angiotensin receptor blockers
  • Angiotensin-converting enzyme-inhibitors
  • Chronic diseases
  • Functional decline
  • Inflammation
  • Physical exercise
  • Statins

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Ageing

Cite this

Targeting inflammation to slow or delay functional decline : Where are we? / Corsonello, Andrea; Garasto, Sabrina; Abbatecola, Angela Marie; Rose, Giuseppina; Passarino, Giuseppe; Mazzei, Bruno; Pranno, Luigi; Guffanti, Enrico Eugenio; Bustacchini, Silvia; Lattanzio, Fabrizia.

In: Biogerontology, Vol. 11, No. 5, 10.2010, p. 603-614.

Research output: Contribution to journalArticle

Corsonello, Andrea ; Garasto, Sabrina ; Abbatecola, Angela Marie ; Rose, Giuseppina ; Passarino, Giuseppe ; Mazzei, Bruno ; Pranno, Luigi ; Guffanti, Enrico Eugenio ; Bustacchini, Silvia ; Lattanzio, Fabrizia. / Targeting inflammation to slow or delay functional decline : Where are we?. In: Biogerontology. 2010 ; Vol. 11, No. 5. pp. 603-614.
@article{292024aa6d5042e58844f24fb3e4ffb2,
title = "Targeting inflammation to slow or delay functional decline: Where are we?",
abstract = "The role of inflammation in the pathophysiology of chronic age-related diseases is increasingly recognized, and inflammation could represent the common pathway linking diseases and disability. Thus, targeting inflammation could represent a useful strategy at preventing or delaying functional decline. In this paper we review recent evidence suggesting that selected drugs, such as statins, fibrates, angiotensin converting enzyme-inhibitors and angiotensin receptor blockers, and physical exercise may be able to contrast functional decline by blunting inflammation. Results from randomized trials investigating the effects of physical activity programs on inflammation and functional decline is still limited, and further investigations are warranted.",
keywords = "Aging, Angiotensin receptor blockers, Angiotensin-converting enzyme-inhibitors, Chronic diseases, Functional decline, Inflammation, Physical exercise, Statins",
author = "Andrea Corsonello and Sabrina Garasto and Abbatecola, {Angela Marie} and Giuseppina Rose and Giuseppe Passarino and Bruno Mazzei and Luigi Pranno and Guffanti, {Enrico Eugenio} and Silvia Bustacchini and Fabrizia Lattanzio",
year = "2010",
month = "10",
doi = "10.1007/s10522-010-9289-0",
language = "English",
volume = "11",
pages = "603--614",
journal = "Biogerontology",
issn = "1389-5729",
publisher = "Springer Netherlands",
number = "5",

}

TY - JOUR

T1 - Targeting inflammation to slow or delay functional decline

T2 - Where are we?

AU - Corsonello, Andrea

AU - Garasto, Sabrina

AU - Abbatecola, Angela Marie

AU - Rose, Giuseppina

AU - Passarino, Giuseppe

AU - Mazzei, Bruno

AU - Pranno, Luigi

AU - Guffanti, Enrico Eugenio

AU - Bustacchini, Silvia

AU - Lattanzio, Fabrizia

PY - 2010/10

Y1 - 2010/10

N2 - The role of inflammation in the pathophysiology of chronic age-related diseases is increasingly recognized, and inflammation could represent the common pathway linking diseases and disability. Thus, targeting inflammation could represent a useful strategy at preventing or delaying functional decline. In this paper we review recent evidence suggesting that selected drugs, such as statins, fibrates, angiotensin converting enzyme-inhibitors and angiotensin receptor blockers, and physical exercise may be able to contrast functional decline by blunting inflammation. Results from randomized trials investigating the effects of physical activity programs on inflammation and functional decline is still limited, and further investigations are warranted.

AB - The role of inflammation in the pathophysiology of chronic age-related diseases is increasingly recognized, and inflammation could represent the common pathway linking diseases and disability. Thus, targeting inflammation could represent a useful strategy at preventing or delaying functional decline. In this paper we review recent evidence suggesting that selected drugs, such as statins, fibrates, angiotensin converting enzyme-inhibitors and angiotensin receptor blockers, and physical exercise may be able to contrast functional decline by blunting inflammation. Results from randomized trials investigating the effects of physical activity programs on inflammation and functional decline is still limited, and further investigations are warranted.

KW - Aging

KW - Angiotensin receptor blockers

KW - Angiotensin-converting enzyme-inhibitors

KW - Chronic diseases

KW - Functional decline

KW - Inflammation

KW - Physical exercise

KW - Statins

UR - http://www.scopus.com/inward/record.url?scp=78049295549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049295549&partnerID=8YFLogxK

U2 - 10.1007/s10522-010-9289-0

DO - 10.1007/s10522-010-9289-0

M3 - Article

C2 - 20549351

AN - SCOPUS:78049295549

VL - 11

SP - 603

EP - 614

JO - Biogerontology

JF - Biogerontology

SN - 1389-5729

IS - 5

ER -