Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen

Marco Lepore, Claudia De Lalla, Lucia Mori, Paolo Dellabona, Gennaro De Libero, Giulia Casorati

Research output: Contribution to journalArticlepeer-review

Abstract

A subset of CD1c-restricted T lymphocytes exhibits strong reactivity against leukemia cells. These T cells recognize methyl-lysophosphatidic acid (mLPA), a novel lipid antigen produced by acute leukemia cells. Considering that CD1crestricted T cells display efficacious anti-leukemia activities in a mouse model, this lipid antigen thus represents a novel target in the immunotherapy of hematological malignancies.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalOncoImmunology
Volume4
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Autoreactivity
  • CD1
  • Immunesurveillance
  • Immunotherapy
  • Leukemia
  • Lipid antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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