Targeting loop adenines in G-quadruplex by a selective oxirane

Filippo Doria; Matteo Nadai; Marco Folini; Matteo Scalabrin; Luca Germani; Giovanna Sattin; Mariella Mella; Manlio Palumbo; Nadia Zaffaroni; Daniele Fabris; Mauro Freccero; Sara N. Richter

doi:10.1002/chem.201203097

Targeting loop adenines in G-quadruplex by a selective oxirane

Filippo Doria, Matteo Nadai, Marco Folini, Matteo Scalabrin, Luca Germani, Giovanna Sattin, Mariella Mella, Manlio Palumbo, Nadia Zaffaroni, Daniele Fabris, Mauro Freccero, Sara N. Richter

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.

Original language	English
Pages (from-to)	78-81
Number of pages	4
Journal	Chemistry - A European Journal
Volume	19
Issue number	1
DOIs	https://doi.org/10.1002/chem.201203097
Publication status	Published - Jan 2 2013

Keywords

alkylation
DNA damage
G-quadruplexes
oxirane
quinone methides

ASJC Scopus subject areas

Chemistry(all)

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10.1002/chem.201203097

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Targeting loop adenines in G-quadruplex by a selective oxirane. / Doria, Filippo; Nadai, Matteo; Folini, Marco; Scalabrin, Matteo; Germani, Luca; Sattin, Giovanna; Mella, Mariella; Palumbo, Manlio; Zaffaroni, Nadia; Fabris, Daniele; Freccero, Mauro; Richter, Sara N.

In: Chemistry - A European Journal, Vol. 19, No. 1, 02.01.2013, p. 78-81.

Research output: Contribution to journal › Article › peer-review

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AU - Germani, Luca

AU - Sattin, Giovanna

AU - Mella, Mariella

AU - Palumbo, Manlio

AU - Zaffaroni, Nadia

AU - Fabris, Daniele

AU - Freccero, Mauro

AU - Richter, Sara N.

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Targeting loop adenines in G-quadruplex by a selective oxirane

Abstract

Keywords

ASJC Scopus subject areas

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