Targeting loop adenines in G-quadruplex by a selective oxirane

Filippo Doria; Matteo Nadai; Marco Folini; Matteo Scalabrin; Luca Germani; Giovanna Sattin; Mariella Mella; Manlio Palumbo; Nadia Zaffaroni; Daniele Fabris; Mauro Freccero; Sara N. Richter

doi:10.1002/chem.201203097

Targeting loop adenines in G-quadruplex by a selective oxirane

Filippo Doria, Matteo Nadai, Marco Folini, Matteo Scalabrin, Luca Germani, Giovanna Sattin, Mariella Mella, Manlio Palumbo, Nadia Zaffaroni, Daniele Fabris, Mauro Freccero, Sara N. Richter

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.

Original language	English
Pages (from-to)	78-81
Number of pages	4
Journal	Chemistry - A European Journal
Volume	19
Issue number	1
DOIs	https://doi.org/10.1002/chem.201203097
Publication status	Published - Jan 2 2013

Keywords

alkylation
DNA damage
G-quadruplexes
oxirane
quinone methides

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1002/chem.201203097

Fingerprint Dive into the research topics of 'Targeting loop adenines in G-quadruplex by a selective oxirane'. Together they form a unique fingerprint.

Cite this

Targeting loop adenines in G-quadruplex by a selective oxirane. / Doria, Filippo; Nadai, Matteo; Folini, Marco; Scalabrin, Matteo; Germani, Luca; Sattin, Giovanna; Mella, Mariella; Palumbo, Manlio; Zaffaroni, Nadia; Fabris, Daniele; Freccero, Mauro; Richter, Sara N.

In: Chemistry - A European Journal, Vol. 19, No. 1, 02.01.2013, p. 78-81.

Research output: Contribution to journal › Article › peer-review

@article{4f57156736ce453199763995061669f0,

title = "Targeting loop adenines in G-quadruplex by a selective oxirane",

abstract = "Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.",

keywords = "alkylation, DNA damage, G-quadruplexes, oxirane, quinone methides",

author = "Filippo Doria and Matteo Nadai and Marco Folini and Matteo Scalabrin and Luca Germani and Giovanna Sattin and Mariella Mella and Manlio Palumbo and Nadia Zaffaroni and Daniele Fabris and Mauro Freccero and Richter, {Sara N.}",

year = "2013",

month = jan,

day = "2",

doi = "10.1002/chem.201203097",

language = "English",

volume = "19",

pages = "78--81",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

number = "1",

}

TY - JOUR

T1 - Targeting loop adenines in G-quadruplex by a selective oxirane

AU - Doria, Filippo

AU - Nadai, Matteo

AU - Folini, Marco

AU - Scalabrin, Matteo

AU - Germani, Luca

AU - Sattin, Giovanna

AU - Mella, Mariella

AU - Palumbo, Manlio

AU - Zaffaroni, Nadia

AU - Fabris, Daniele

AU - Freccero, Mauro

AU - Richter, Sara N.

PY - 2013/1/2

Y1 - 2013/1/2

N2 - Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.

AB - Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.

KW - alkylation

KW - DNA damage

KW - G-quadruplexes

KW - oxirane

KW - quinone methides

UR - http://www.scopus.com/inward/record.url?scp=84871533376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871533376&partnerID=8YFLogxK

U2 - 10.1002/chem.201203097

DO - 10.1002/chem.201203097

M3 - Article

C2 - 23212868

AN - SCOPUS:84871533376

VL - 19

SP - 78

EP - 81

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 1

ER -