Targeting loop adenines in G-quadruplex by a selective oxirane

Filippo Doria, Matteo Nadai, Marco Folini, Matteo Scalabrin, Luca Germani, Giovanna Sattin, Mariella Mella, Manlio Palumbo, Nadia Zaffaroni, Daniele Fabris, Mauro Freccero, Sara N. Richter

Research output: Contribution to journalArticlepeer-review

Abstract

Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalChemistry - A European Journal
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2 2013

Keywords

  • alkylation
  • DNA damage
  • G-quadruplexes
  • oxirane
  • quinone methides

ASJC Scopus subject areas

  • Chemistry(all)

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