Abstract
Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.
Original language | English |
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Pages (from-to) | 78-81 |
Number of pages | 4 |
Journal | Chemistry - A European Journal |
Volume | 19 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2 2013 |
Keywords
- alkylation
- DNA damage
- G-quadruplexes
- oxirane
- quinone methides
ASJC Scopus subject areas
- Chemistry(all)