Targeting MicroRNAs to withstand cancer metastasis

Valentina Profumo, Valentina Doldi, Paolo Gandellini, Nadia Zaffaroni

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

MicroRNAs are endogenous, regulatory, noncoding small RNAs shown to play a key role in controlling gene expression, mainly at the posttranscriptional level. Several lines of evidence highlighted the importance of selected microRNAs as essential actors of cancer initiation events, tumor progression towards malignancy, and ultimately metastasis. By acting as either prometastatic or antimetastatic factors, microRNAs may represent novel targets or tools to withstand cancer progression. This chapter summarizes the available strategies to manipulate the expression of metastasis-related microRNAs, either by mimicking or inhibiting them, in cell systems and in vivo models. In addition, we provide a broad overview of conceptual and technological issues that need to be addressed before microRNAs might be exploited in the clinical setting for the prevention and treatment of the metastatic disease.

Original languageEnglish
Title of host publicationRNA Interference: Challenges and Therapeutic Opportunities
PublisherSpringer New York
Pages415-437
Number of pages23
ISBN (Print)9781493915385, 9781493915378
DOIs
Publication statusPublished - Oct 15 2014

Fingerprint

MicroRNAs
Neoplasm Metastasis
Neoplasms
Small Untranslated RNA
Gene Expression

Keywords

  • Cancer metastasis
  • microRNA
  • miRNA inhibitors
  • miRNA mimics
  • miRNA-based therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Profumo, V., Doldi, V., Gandellini, P., & Zaffaroni, N. (2014). Targeting MicroRNAs to withstand cancer metastasis. In RNA Interference: Challenges and Therapeutic Opportunities (pp. 415-437). Springer New York. https://doi.org/10.1007/978-1-4939-1538-5_25

Targeting MicroRNAs to withstand cancer metastasis. / Profumo, Valentina; Doldi, Valentina; Gandellini, Paolo; Zaffaroni, Nadia.

RNA Interference: Challenges and Therapeutic Opportunities. Springer New York, 2014. p. 415-437.

Research output: Chapter in Book/Report/Conference proceedingChapter

Profumo, V, Doldi, V, Gandellini, P & Zaffaroni, N 2014, Targeting MicroRNAs to withstand cancer metastasis. in RNA Interference: Challenges and Therapeutic Opportunities. Springer New York, pp. 415-437. https://doi.org/10.1007/978-1-4939-1538-5_25
Profumo V, Doldi V, Gandellini P, Zaffaroni N. Targeting MicroRNAs to withstand cancer metastasis. In RNA Interference: Challenges and Therapeutic Opportunities. Springer New York. 2014. p. 415-437 https://doi.org/10.1007/978-1-4939-1538-5_25
Profumo, Valentina ; Doldi, Valentina ; Gandellini, Paolo ; Zaffaroni, Nadia. / Targeting MicroRNAs to withstand cancer metastasis. RNA Interference: Challenges and Therapeutic Opportunities. Springer New York, 2014. pp. 415-437
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