Abstract
Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.
| Original language | English |
|---|---|
| Article number | 604685 |
| Journal | TheScientificWorldJournal |
| Volume | 2014 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Environmental Science(all)
- Medicine(all)
Cite this
Targeting mitochondria as therapeutic strategy for metabolic disorders. / Sorriento, Daniela; Pascale, Antonietta Valeria; Finelli, Rosa; Carillo, Anna Lisa; Annunziata, Roberto; Trimarco, Bruno; Iaccarino, Guido.
In: TheScientificWorldJournal, Vol. 2014, 604685, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Targeting mitochondria as therapeutic strategy for metabolic disorders
AU - Sorriento, Daniela
AU - Pascale, Antonietta Valeria
AU - Finelli, Rosa
AU - Carillo, Anna Lisa
AU - Annunziata, Roberto
AU - Trimarco, Bruno
AU - Iaccarino, Guido
PY - 2014
Y1 - 2014
N2 - Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.
AB - Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.
UR - http://www.scopus.com/inward/record.url?scp=84897529482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897529482&partnerID=8YFLogxK
U2 - 10.1155/2014/604685
DO - 10.1155/2014/604685
M3 - Article
C2 - 24757426
AN - SCOPUS:84897529482
VL - 2014
JO - The Scientific World Journal
JF - The Scientific World Journal
SN - 2356-6140
M1 - 604685
ER -