Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion

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Abstract

Tumor development and progression are strongly linked to inflammation and the presence of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling, or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of conventional cancer therapeutic strategies by targeting TAMs.

Original languageEnglish
Pages (from-to)9113-9116
Number of pages4
JournalCancer Research
Volume65
Issue number20
DOIs
Publication statusPublished - Oct 15 2005

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Inflammation
Neoplasms
Macrophages
Extracellular Matrix
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion. / Colombo, Mario P.; Mantovani, Alberto.

In: Cancer Research, Vol. 65, No. 20, 15.10.2005, p. 9113-9116.

Research output: Contribution to journalArticle

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