Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases

Maurizio Forte, V. Conti, Antonio Damato, Mariateresa Ambrosio, Annibale Alessandro Puca, Sebastiano Sciarretta, Giacomo Frati, Carmine Vecchione, Albino Carrizzo

Research output: Contribution to journalArticle

Abstract

Within the family of endogenous gasotransmitters, nitric oxide (NO) is the smallest gaseous intercellular messenger involved in the modulation of several processes, such as blood flow and platelet aggregation control, essential to maintain vascular homeostasis. NO is produced by nitric oxide synthases (NOS) and its effects are mediated by cGMP-dependent or cGMP-independent mechanisms. Growing evidence suggests a crosstalk between the NO signaling and the occurrence of oxidative stress in the onset and progression of vascular diseases, such as hypertension, heart failure, ischemia, and stroke. For these reasons, NO is considered as an emerging molecular target for developing therapeutic strategies for cardio- and cerebrovascular pathologies. Several natural derived compounds, such as polyphenols, are now proposed as modulators of NO-mediated pathways. The aim of this review is to highlight the experimental evidence on the involvement of nitric oxide in vascular homeostasis focusing on the therapeutic potential of targeting NO with some natural compounds in patients with vascular diseases.

Original languageEnglish
Article number7364138
JournalOxidative Medicine and Cellular Longevity
Volume2016
DOIs
Publication statusPublished - 2016

Fingerprint

Vascular Diseases
Nitric Oxide
Therapeutics
Blood Vessels
Gasotransmitters
Homeostasis
Oxidative stress
Polyphenols
Pathology
Crosstalk
Platelets
Platelet Aggregation
Nitric Oxide Synthase
Modulators
Oxidative Stress
Blood
Blood Platelets
Ischemia
Agglomeration
Heart Failure

ASJC Scopus subject areas

  • Cell Biology
  • Ageing
  • Biochemistry

Cite this

Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases. / Forte, Maurizio; Conti, V.; Damato, Antonio; Ambrosio, Mariateresa; Puca, Annibale Alessandro; Sciarretta, Sebastiano; Frati, Giacomo; Vecchione, Carmine; Carrizzo, Albino.

In: Oxidative Medicine and Cellular Longevity, Vol. 2016, 7364138, 2016.

Research output: Contribution to journalArticle

Forte, M, Conti, V, Damato, A, Ambrosio, M, Puca, AA, Sciarretta, S, Frati, G, Vecchione, C & Carrizzo, A 2016, 'Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases', Oxidative Medicine and Cellular Longevity, vol. 2016, 7364138. https://doi.org/10.1155/2016/7364138
Forte, Maurizio ; Conti, V. ; Damato, Antonio ; Ambrosio, Mariateresa ; Puca, Annibale Alessandro ; Sciarretta, Sebastiano ; Frati, Giacomo ; Vecchione, Carmine ; Carrizzo, Albino. / Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases. In: Oxidative Medicine and Cellular Longevity. 2016 ; Vol. 2016.
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