Targeting pericranial nerve branches to treat migraine: Current approaches and perspectives

Anna Ambrosini, Carmelo D'Alessio, Delphine Magis, Jean Schoenen

Research output: Contribution to journalArticlepeer-review


Background Migraine is a highly prevalent neurological disorders and a major individual and societal burden. Migraine is not curable at the present time, but it is amenable to acute symptomatic and preventive pharmacotherapies. Summary Since the latter are frequently unsatisfactory, other treatment strategies have been used or are being explored. In particular, interventions targeting pericranial nerves are now part of the migraine armamentarium. We will critically review some of them, such as invasive and noninvasive neurostimulation, therapeutic blocks and surgical decompressions. Conclusions Although current knowledge on migraine pathophysiology suggests a central nervous system dysfunction, there is some evidence that interventions targeting peripheral nerves are able to modulate neuronal circuits involved in pain control and that they could be useful in some selected patients. Larger, well-designed and comparative trials are needed to appraise the respective advantages, disadvantages and indications of most interventions discussed here.

Original languageEnglish
Pages (from-to)1308-1322
Number of pages15
Issue number14
Publication statusPublished - Dec 1 2015


  • blocks
  • Migraine
  • neurostimulation
  • pericranial nerves
  • surgery
  • treatment

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Targeting pericranial nerve branches to treat migraine: Current approaches and perspectives'. Together they form a unique fingerprint.

Cite this