Targeting PKCθ in skeletal muscle and muscle diseases: Good or bad?

Valeria Marrocco, Piera Fiore, Luca Madaro, Annunziata Crupi, Biliana Lozanoska-Ochser, Marina Bouché

Research output: Contribution to journalArticle

Abstract

Protein kinase Cθ (PKCθ) is a member of the novel calcium-independent PKC family, with a relatively selective tissue distribution. Most studies have focused on its unique role in T-lymphocyte activation and suggest that inhibition of PKCθ could represent a novel therapeutic approach in the treatment of chronic inflammation, autoimmunity and allograft rejection. However, considering that PKCθ is also expressed in other cell types, including skeletal muscle cells, it is important to understand its function in different tissues before proposing it as a molecular target for the treatment of immune-mediated diseases. A number of studies have highlighted the role of PKCθ in mediating several intracellular pathways, regulating muscle cell development, homoeostasis and remodelling, although a comprehensive picture is still lacking. Moreover, we recently showed that lack of PKCθ in a mouse model of Duchenne muscular dystrophy (DMD) ameliorates the progression of the disease. In the present article, we review new developments in our understanding of the involvement of PKCθ in intracellular mechanisms regulating skeletal muscle development, growth and maintenance under physiological conditions and recent advances showing a hitherto unrecognized role of PKCθ in promoting muscular dystrophy.

Original languageEnglish
Pages (from-to)1550-1555
Number of pages6
JournalBiochemical Society Transactions
Volume42
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

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Keywords

  • Muscle development
  • Muscle maintenance
  • Muscular dystrophy
  • Protein kinase Cθ (PKCθ)
  • Skeletal muscle

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)

Cite this

Marrocco, V., Fiore, P., Madaro, L., Crupi, A., Lozanoska-Ochser, B., & Bouché, M. (2014). Targeting PKCθ in skeletal muscle and muscle diseases: Good or bad? Biochemical Society Transactions, 42(6), 1550-1555. https://doi.org/10.1042/BST20140207