Targeting Plasmodium host cells: Survival within hepatocytes

Maria M. Mota, Silvia Giordano, Ana Rodriguez

Research output: Contribution to journalArticlepeer-review


Upon entering their host, Plasmodium sporozoites travel directly to the liver. Once there, they migrate through several hepatocytes before they infect a final one. During migration, sporozoites breach the plasma membrane of traversed hepatocytes, but to infect they must form a parasitophorous vacuole, in which the intra-hepatic form of the parasite grows and multiplies. During this period there is a remarkable parasite multiplication, but little is known about the requirements and strategies that are developed to be successful. Hepatocyte growth factor and its receptor on hepatocytes might enhance early Plasmodium development within these cells. We anticipate that this might be the basis for further studies on host-cell requirements for Plasmodium development.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalTrends in Molecular Medicine
Issue number10
Publication statusPublished - Oct 2004

ASJC Scopus subject areas

  • Medicine(all)


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