TY - JOUR
T1 - Targeting Stem Cells with Hyperthermia: Translational Relevance in Cancer Patients.
AU - Ammendola, Michele
AU - Currò, Giuseppe
AU - Memeo, Riccardo
AU - Curto, Lucia Stella
AU - Luposella, Maria
AU - Zuccalà, Valeria
AU - Pessaux, Patrick
AU - Navarra, Giuseppe
AU - Gadaleta, Cosmo Damiano
AU - Ranieri, Girolamo
N1 - Publisher Copyright:
© 2020 S. Karger AG, Basel.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Background: Tumor recurrences or metastases remain a major hurdle in improving overall cancer survival. In anticancer therapy, some patients inevitably develop chemo-/radiotherapy resistance at some point. Cancer stem cells are the driving force of tumorigenesis, recurrences, and metastases, contributing also to the failure of some cancer treatments. Summary: Emergent evidence suggests that stem cell diseases are at the base of human cancers, and tumor progression and chemo-/radiotherapy resistance may be dependent on just a small subpopulation of cancer stem cells. Hyperthermia can be a strong cancer treatment, especially when combined with radio- or chemotherapy. It is a relatively safe therapy, may kill or weaken tumor cells, and significantly increases the effectiveness of other treatments. However, these mechanisms remain largely unknown. A literature search was performed using PubMed including cited English publications. The search was last conducted in December 2019. Search phrases included "stem cells,""hyperthermia,""cancer,"and "therapy."Abstracts, letters, editorials, and expert opinions were not considered for the drafting of the study. Key Message: Our goal was to focus on and to summarize different biological features of cancer stem cells and new therapeutic approaches using hyperthermia and its potential translation to human clinical trials.
AB - Background: Tumor recurrences or metastases remain a major hurdle in improving overall cancer survival. In anticancer therapy, some patients inevitably develop chemo-/radiotherapy resistance at some point. Cancer stem cells are the driving force of tumorigenesis, recurrences, and metastases, contributing also to the failure of some cancer treatments. Summary: Emergent evidence suggests that stem cell diseases are at the base of human cancers, and tumor progression and chemo-/radiotherapy resistance may be dependent on just a small subpopulation of cancer stem cells. Hyperthermia can be a strong cancer treatment, especially when combined with radio- or chemotherapy. It is a relatively safe therapy, may kill or weaken tumor cells, and significantly increases the effectiveness of other treatments. However, these mechanisms remain largely unknown. A literature search was performed using PubMed including cited English publications. The search was last conducted in December 2019. Search phrases included "stem cells,""hyperthermia,""cancer,"and "therapy."Abstracts, letters, editorials, and expert opinions were not considered for the drafting of the study. Key Message: Our goal was to focus on and to summarize different biological features of cancer stem cells and new therapeutic approaches using hyperthermia and its potential translation to human clinical trials.
KW - Cancer
KW - Cancer stem cells
KW - Hyperthermia
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=85090123307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090123307&partnerID=8YFLogxK
U2 - 10.1159/000509039
DO - 10.1159/000509039
M3 - Review article
C2 - 32784294
AN - SCOPUS:85090123307
VL - 98
SP - 755
EP - 762
JO - Oncology
JF - Oncology
SN - 0030-2414
IS - 11
ER -