Targeting survivin in cancer therapy: Fulfilled promises and open questions

Marzia Pennati, Marco Folini, Nadia Zaffaroni

Research output: Contribution to journalArticle

Abstract

Survivin is a bifunctional protein that acts as a suppressor of apoptosis and plays a central role in cell division. The protein is strongly expressed in the most common human neoplasms, has prognostic relevance for some of them and appears to be involved in tumor cell resistance to anticancer agents and ionizing radiation. On the basis of these findings, survivin has been proposed as an attractive target for new anticancer interventions. Several preclinical studies have demonstrated that down-regulation of survivin expression or function, accomplished by means of various strategies, reduced tumor growth potential, increased the apoptotic rate and sensitized tumor cells to chemotherapeutic drugs and radiation in different human tumor models. Moreover, the first survivin inhibitors recently entered clinical trials. Recent studies suggest a possible role for survivin in regulating the function of normal adult cells. However, the expression and function of survivin in normal tissues are still not well characterized and understood. Better knowledge of the role of survivin in tumor versus normal cells will be instrumental for the design of optimal strategies to selectively disrupt survivin in cancer.

Original languageEnglish
Pages (from-to)1133-1139
Number of pages7
JournalCarcinogenesis
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2007

ASJC Scopus subject areas

  • Cancer Research

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