Abstract
Survivin is a structurally unique member of the inhibitor of apoptosis protein family that in addition to acting as a suppressor of programmed cell death also plays a central role in cell division. Owing to its massive up-regulation in human tumors and its involvement in cancer progression and treatment resistance, survivin is currently undergoing extensive investigation as a promising target for new anticancer interventions. Several preclinical studies have demonstrated that down-regulation of survivin expression or function, accomplished by means of various strategies (including the use of antisense oligonucleotides, small interfering RNAs, ribozymes, dominant negative mutants and small molecule antagonists), reduced tumor growth potential, increased the apoptotic rate, and sensitized tumor cells to chemotherapeutic drugs and ionizing radiation in different human tumor preclinical models. Moreover, the first survivin inhibitors have already reached the clinic with some promise. However, due to its documented role in some normal tissues, the possibility that survivin disruption could affect normal cell function, mainly the hematopoietic and immune systems, cannot be excluded. In this context, a better understanding of the effects exerted by survivin on normal versus malignant cells will be important for the design of optimal strategies to selectively disrupt survivin in cancer.
| Original language | English |
|---|---|
| Title of host publication | Apoptosome: An Up-and-coming Therapeutical Tool |
| Publisher | Springer Netherlands |
| Pages | 147-168 |
| Number of pages | 22 |
| ISBN (Print) | 9789048134151, 9789048134144 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Apoptosis
- Cell cycle
- Human cancers
- Inhibitors of apoptosis-proteins
- Survivin
ASJC Scopus subject areas
- Medicine(all)
Cite this
Targeting survivin in cancer therapy : Pre-clinical studies. / Pennati, Marzia; Folini, Marco; Zaffaroni, Nadia.
Apoptosome: An Up-and-coming Therapeutical Tool. Springer Netherlands, 2010. p. 147-168.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Targeting survivin in cancer therapy
T2 - Pre-clinical studies
AU - Pennati, Marzia
AU - Folini, Marco
AU - Zaffaroni, Nadia
PY - 2010
Y1 - 2010
N2 - Survivin is a structurally unique member of the inhibitor of apoptosis protein family that in addition to acting as a suppressor of programmed cell death also plays a central role in cell division. Owing to its massive up-regulation in human tumors and its involvement in cancer progression and treatment resistance, survivin is currently undergoing extensive investigation as a promising target for new anticancer interventions. Several preclinical studies have demonstrated that down-regulation of survivin expression or function, accomplished by means of various strategies (including the use of antisense oligonucleotides, small interfering RNAs, ribozymes, dominant negative mutants and small molecule antagonists), reduced tumor growth potential, increased the apoptotic rate, and sensitized tumor cells to chemotherapeutic drugs and ionizing radiation in different human tumor preclinical models. Moreover, the first survivin inhibitors have already reached the clinic with some promise. However, due to its documented role in some normal tissues, the possibility that survivin disruption could affect normal cell function, mainly the hematopoietic and immune systems, cannot be excluded. In this context, a better understanding of the effects exerted by survivin on normal versus malignant cells will be important for the design of optimal strategies to selectively disrupt survivin in cancer.
AB - Survivin is a structurally unique member of the inhibitor of apoptosis protein family that in addition to acting as a suppressor of programmed cell death also plays a central role in cell division. Owing to its massive up-regulation in human tumors and its involvement in cancer progression and treatment resistance, survivin is currently undergoing extensive investigation as a promising target for new anticancer interventions. Several preclinical studies have demonstrated that down-regulation of survivin expression or function, accomplished by means of various strategies (including the use of antisense oligonucleotides, small interfering RNAs, ribozymes, dominant negative mutants and small molecule antagonists), reduced tumor growth potential, increased the apoptotic rate, and sensitized tumor cells to chemotherapeutic drugs and ionizing radiation in different human tumor preclinical models. Moreover, the first survivin inhibitors have already reached the clinic with some promise. However, due to its documented role in some normal tissues, the possibility that survivin disruption could affect normal cell function, mainly the hematopoietic and immune systems, cannot be excluded. In this context, a better understanding of the effects exerted by survivin on normal versus malignant cells will be important for the design of optimal strategies to selectively disrupt survivin in cancer.
KW - Apoptosis
KW - Cell cycle
KW - Human cancers
KW - Inhibitors of apoptosis-proteins
KW - Survivin
UR - http://www.scopus.com/inward/record.url?scp=80052476181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052476181&partnerID=8YFLogxK
U2 - 10.1007/978-90-481-3415-1-8
DO - 10.1007/978-90-481-3415-1-8
M3 - Chapter
SN - 9789048134151
SN - 9789048134144
SP - 147
EP - 168
BT - Apoptosome: An Up-and-coming Therapeutical Tool
PB - Springer Netherlands
ER -