Targeting the extracellular signature of metastatic colorectal cancers

Serena Marchi, Wadih Arap, Renata Pasqualini

Research output: Contribution to journalArticlepeer-review


Background : Colorectal cancer is a leading cause of tumor death, a consequence primarily of the spreading of malignant cells to liver and lung. Despite a range of interventions for liver metastases, the present knowledge of few specific molecular targets may contribute to late diagnosis and poorly effective therapy. Objective : To review the most innovative methodology employed to profile the signature(s) of metastatic colorectal cancer (mCRC) and to address diagnostic/therapeutic agents. Methods : A broad range Medline search was conducted, with particular attention to the search terms 'liver metastasis signature', in combination with 'targeting' and 'nanotechnology'. Results/conclusions : Studies aimed at the discovery of molecular signatures of cancers and metastasis are ongoing; the future of cancer/metastasis targeting is nanoparticle-mediated drug delivery.

Original languageEnglish
Pages (from-to)363-379
Number of pages17
JournalExpert Opinion on Therapeutic Targets
Issue number3
Publication statusPublished - Mar 2009


  • Metastatic colorectal cancer
  • Phage display
  • Targeted therapy

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine


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