Targeting the extracellular signature of metastatic colorectal cancers

Serena Marchi, Wadih Arap, Renata Pasqualini

Research output: Contribution to journalArticle

Abstract

Background : Colorectal cancer is a leading cause of tumor death, a consequence primarily of the spreading of malignant cells to liver and lung. Despite a range of interventions for liver metastases, the present knowledge of few specific molecular targets may contribute to late diagnosis and poorly effective therapy. Objective : To review the most innovative methodology employed to profile the signature(s) of metastatic colorectal cancer (mCRC) and to address diagnostic/therapeutic agents. Methods : A broad range Medline search was conducted, with particular attention to the search terms 'liver metastasis signature', in combination with 'targeting' and 'nanotechnology'. Results/conclusions : Studies aimed at the discovery of molecular signatures of cancers and metastasis are ongoing; the future of cancer/metastasis targeting is nanoparticle-mediated drug delivery.

Original languageEnglish
Pages (from-to)363-379
Number of pages17
JournalExpert Opinion on Therapeutic Targets
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Liver
Colorectal Neoplasms
Neoplasm Metastasis
Drug delivery
Nanotechnology
Neoplasms
Tumors
Delayed Diagnosis
Nanoparticles
Cause of Death
Lung
Therapeutics
Pharmaceutical Preparations

Keywords

  • Metastatic colorectal cancer
  • Phage display
  • Targeted therapy

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Targeting the extracellular signature of metastatic colorectal cancers. / Marchi, Serena; Arap, Wadih; Pasqualini, Renata.

In: Expert Opinion on Therapeutic Targets, Vol. 13, No. 3, 03.2009, p. 363-379.

Research output: Contribution to journalArticle

Marchi, Serena ; Arap, Wadih ; Pasqualini, Renata. / Targeting the extracellular signature of metastatic colorectal cancers. In: Expert Opinion on Therapeutic Targets. 2009 ; Vol. 13, No. 3. pp. 363-379.
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