Abstract
Background : Colorectal cancer is a leading cause of tumor death, a consequence primarily of the spreading of malignant cells to liver and lung. Despite a range of interventions for liver metastases, the present knowledge of few specific molecular targets may contribute to late diagnosis and poorly effective therapy. Objective : To review the most innovative methodology employed to profile the signature(s) of metastatic colorectal cancer (mCRC) and to address diagnostic/therapeutic agents. Methods : A broad range Medline search was conducted, with particular attention to the search terms 'liver metastasis signature', in combination with 'targeting' and 'nanotechnology'. Results/conclusions : Studies aimed at the discovery of molecular signatures of cancers and metastasis are ongoing; the future of cancer/metastasis targeting is nanoparticle-mediated drug delivery.
Original language | English |
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Pages (from-to) | 363-379 |
Number of pages | 17 |
Journal | Expert Opinion on Therapeutic Targets |
Volume | 13 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2009 |
Keywords
- Metastatic colorectal cancer
- Phage display
- Targeted therapy
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Clinical Biochemistry
- Molecular Medicine