Targeting the inflammation in HCV-associated hepatocellular carcinoma: A role in the prevention and treatment

Giuseppe Castello, Susan Costantini, Stefania Scala

Research output: Contribution to journalArticle

Abstract

Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kines, reactive oxygen species (ROS) and nitric oxide (NO), generating cell transformation. We suggest hepatocarcinoma (HCC) as a model in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemoprevention targeting the microenvironment.

Original languageEnglish
Article number109
JournalJournal of Translational Medicine
Volume8
DOIs
Publication statusPublished - Nov 3 2010

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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