TY - JOUR
T1 - Targeting the inflammation in HCV-associated hepatocellular carcinoma
T2 - A role in the prevention and treatment
AU - Castello, Giuseppe
AU - Costantini, Susan
AU - Scala, Stefania
PY - 2010/11/3
Y1 - 2010/11/3
N2 - Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kines, reactive oxygen species (ROS) and nitric oxide (NO), generating cell transformation. We suggest hepatocarcinoma (HCC) as a model in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemoprevention targeting the microenvironment.
AB - Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kines, reactive oxygen species (ROS) and nitric oxide (NO), generating cell transformation. We suggest hepatocarcinoma (HCC) as a model in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemoprevention targeting the microenvironment.
UR - http://www.scopus.com/inward/record.url?scp=78049324216&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049324216&partnerID=8YFLogxK
U2 - 10.1186/1479-5876-8-109
DO - 10.1186/1479-5876-8-109
M3 - Article
C2 - 21047421
AN - SCOPUS:78049324216
VL - 8
JO - Journal of Translational Medicine
JF - Journal of Translational Medicine
SN - 1479-5876
M1 - 109
ER -