Abstract
Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kines, reactive oxygen species (ROS) and nitric oxide (NO), generating cell transformation. We suggest hepatocarcinoma (HCC) as a model in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemoprevention targeting the microenvironment.
| Original language | English |
|---|---|
| Article number | 109 |
| Journal | Journal of Translational Medicine |
| Volume | 8 |
| DOIs | |
| Publication status | Published - Nov 3 2010 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
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Cite this
Castello, G., Costantini, S., & Scala, S. (2010). Targeting the inflammation in HCV-associated hepatocellular carcinoma: A role in the prevention and treatment. Journal of Translational Medicine, 8, [109]. https://doi.org/10.1186/1479-5876-8-109