Targeting the JNK pathway as a therapeutic protective strategy for nervous system diseases

Christophe Bonny, Tiziana Borsello, Azel Zine

Research output: Contribution to journalArticlepeer-review

Abstract

The c-Jun N-terminal kinases (JNKs) are members of the family of mitogen activated protein kinases (MAPKs). While the functions of the JNICs under physiological conditions are diverse and not completely understood, there is increasing evidence that JNKs are potent effectors of apoptosis in both the brain and the mammalian inner ear following a variety of injuries. The activation of the inducible transcription factor c-Jun by N-terminal phosphorylation is a central event in JNK-mediated neural and inner ear hair cell death. A cell permeable peptide designed specifically to inhibit JNK signaling has proven successful in in vivo models of both neuronal degeneration following cerebral ischemia and auditory hair cell degeneration following exposure to either acoustic trauma or a toxic level of an aminoglycoside antibiotic. Here we discuss the evidence supporting the application of JNK inhibitors to prevent cellular degeneration in several central nervous system (CNS) and peripheral nervous system (PNS) diseases with an emphasis on traumatic ischemic damage to the CNS and acquired deafness in the PNS receptors.

Original languageEnglish
Pages (from-to)57-67
Number of pages11
JournalReviews in the Neurosciences
Volume16
Issue number1
Publication statusPublished - 2005

Keywords

  • Apoptosis
  • c-Jun N-terminal kinase (JNK)
  • D-JNKI-1 peptide
  • Hearing loss
  • Ischemic damage
  • JNK inhibition
  • Signaling pathways

ASJC Scopus subject areas

  • Neuroscience(all)

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