Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management

M. Gambuzza; N. Licata; E. Palella; D. Celi; V. Foti Cuzzola; D. Italiano; S. Marino; P. Bramanti

doi:10.1016/j.jneuroim.2011.08.010

Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management

M. Gambuzza, N. Licata, E. Palella, D. Celi, V. Foti Cuzzola, D. Italiano, S. Marino, P. Bramanti

IRCCS Centro Neurolesi "Bonino Pulejo"

Research output: Contribution to journal › Article

Abstract

Toll-like receptors (TLR) are important innate immune proteins for the identification and clearance of invading pathogen. TLR signal through adaptor proteins, most commonly myeloid differentiation primary response gene 88 (MyD88). Inappropriate response of specific TLR has been implicated in certain autoimmune diseases, such as multiple sclerosis (MS). Activation of TLR2, TLR4, TLR7 and TLR9 plays a role in experimental allergic encephalomyelitis (EAE), a murine model of MS, while TLR3 activation protects from disease. Therefore, TLR-modulation could be an important adjuvant to current treatments. Here, we focus on TLR involved in EAE and MS pathogenesis highlighting specific components targeting TLR that might offer further therapeutic possibilities.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Journal of Neuroimmunology
Volume	239
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2011.08.010
Publication status	Published - Oct 28 2011

Keywords

Innovative therapeutics
Multiple sclerosis
Receptor-targeting
Toll-like receptors

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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Gambuzza, M., Licata, N., Palella, E., Celi, D., Foti Cuzzola, V., Italiano, D., Marino, S., & Bramanti, P. (2011). Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management. Journal of Neuroimmunology, 239(1-2), 1-12. https://doi.org/10.1016/j.jneuroim.2011.08.010

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AU - Marino, S.

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