Targeting tumour-associated macrophages

Antonio Sica, Luca Rubino, Alessandra Mancino, Paola Larghi, Chiara Porta, Monica Rimoldi, Graziella Solinas, Massino Locati, Paola Avellana, Alberto Mantovani

Research output: Contribution to journalArticle

Abstract

Clinical and experimental evidence have highlighted that a major leukocyte population present in tumours, the so-called tumour-associated macrophages (TAM), is the principal component of the leukocyte infiltrate supporting tumour growth. Over the years the mechanisms supporting the protumoural functions of TAM have become increasingly clear and in several experimental tumour models, the activation of an inflammatory response (most frequently mediated by macrophages) has been shown to play an essential role for full neoplastic transformation and progression. This evidence strongly supports the idea that TAM are central orchestrators of the inflammatory networks expressed in the tumour microenvironment, and suggest these cells as possible targets of anticancer therapies.

Original languageEnglish
Pages (from-to)1219-1229
Number of pages11
JournalExpert Opinion on Therapeutic Targets
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 2007

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Keywords

  • Macrophage polarisation
  • Tumour promotion
  • Tumour-associated macrophage

ASJC Scopus subject areas

  • Molecular Medicine
  • Biochemistry, Genetics and Molecular Biology(all)

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