TY - JOUR
T1 - Targeting tumour-associated macrophages
AU - Sica, Antonio
AU - Rubino, Luca
AU - Mancino, Alessandra
AU - Larghi, Paola
AU - Porta, Chiara
AU - Rimoldi, Monica
AU - Solinas, Graziella
AU - Locati, Massino
AU - Avellana, Paola
AU - Mantovani, Alberto
PY - 2007/9
Y1 - 2007/9
N2 - Clinical and experimental evidence have highlighted that a major leukocyte population present in tumours, the so-called tumour-associated macrophages (TAM), is the principal component of the leukocyte infiltrate supporting tumour growth. Over the years the mechanisms supporting the protumoural functions of TAM have become increasingly clear and in several experimental tumour models, the activation of an inflammatory response (most frequently mediated by macrophages) has been shown to play an essential role for full neoplastic transformation and progression. This evidence strongly supports the idea that TAM are central orchestrators of the inflammatory networks expressed in the tumour microenvironment, and suggest these cells as possible targets of anticancer therapies.
AB - Clinical and experimental evidence have highlighted that a major leukocyte population present in tumours, the so-called tumour-associated macrophages (TAM), is the principal component of the leukocyte infiltrate supporting tumour growth. Over the years the mechanisms supporting the protumoural functions of TAM have become increasingly clear and in several experimental tumour models, the activation of an inflammatory response (most frequently mediated by macrophages) has been shown to play an essential role for full neoplastic transformation and progression. This evidence strongly supports the idea that TAM are central orchestrators of the inflammatory networks expressed in the tumour microenvironment, and suggest these cells as possible targets of anticancer therapies.
KW - Macrophage polarisation
KW - Tumour promotion
KW - Tumour-associated macrophage
UR - http://www.scopus.com/inward/record.url?scp=34548864683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548864683&partnerID=8YFLogxK
U2 - 10.1517/14728222.11.9.1219
DO - 10.1517/14728222.11.9.1219
M3 - Article
C2 - 17845147
AN - SCOPUS:34548864683
VL - 11
SP - 1219
EP - 1229
JO - Expert Opinion on Therapeutic Targets
JF - Expert Opinion on Therapeutic Targets
SN - 1472-8222
IS - 9
ER -