Targeting ubiquitin in cancers

Ivan Dikic, Nicola Crosetto, Silvia Calatroni, Paolo Bernasconi

Research output: Contribution to journalArticle

Abstract

Ubiquitin (Ub) is a small protein modifier involved in cellular functions such as cell cycle, apoptosis, cell signalling, endocytosis, transcription and DNA repair. Ubiquitin operates as a reversible and highly versatile regulatory signal, which may be read and interpreted by an expanding number of Ub-binding domains (UBD). There is accumulating evidence that mutations or altered expression of ubiquitylating or de-ubiquitylating enzymes as well as of Ub-binding proteins affect crucial mediators of such functions and are found in several malignancies. Here we discuss how oncogenic alterations in the Ub system can be targeted by anti-cancer therapies.

Original languageEnglish
Pages (from-to)3095-3102
Number of pages8
JournalEuropean Journal of Cancer
Volume42
Issue number18
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Bortezomib
  • Leukaemia
  • Lymphoma
  • Multiple myeloma
  • Ub system-targeted drugs
  • Ubiquitin

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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