Task-specific impairment of motor cortical excitation and inhibition in patients with writer's cramp

Michele Tinazzi, Simona Farina, Mark Edwards, Giuseppe Moretto, Domenico Restivo, Antonio Fiaschi, Alfredo Berardelli

Research output: Contribution to journalArticle

Abstract

Abnormalities in motor cortical excitation and inhibition have been reported in patients with writer's cramp, at rest and during muscle activation. We were interested in whether such abnormalities might be task-specific and depended on the type of movement task used to activate the dystonic hand. We therefore assessed motor-evoked potentials (facilitation/rest MEP amplitude ratio) and duration of the cortical silent period (CSP) from the right first dorsal interosseus (FDI) muscle to transcranial magnetic stimulation (TMS) in 10 patients with writer's cramp and in 10 healthy volunteers performing pincer and power gripping tasks. The mean facilitation/rest MEP amplitude ratio measured during the pincer grip task was significantly larger in dystonic subjects than in controls, but in the power grip condition was similar in the two groups. The CSP measured in the power grip condition was of similar length in normal controls and dystonic subjects, but in the pincer grip condition was significantly shorter in patients than in controls. These results indicate a task-specific impairment of motor cortical excitation and inhibition in writer's cramp.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalNeuroscience Letters
Volume378
Issue number1
DOIs
Publication statusPublished - Apr 11 2005

Keywords

  • Dystonia
  • Magnetic stimulation
  • Motor control
  • Motor cortex
  • Sensorimotor integration
  • Task-dependence

ASJC Scopus subject areas

  • Neuroscience(all)

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