Taste acceptability of pulverized brand-name and generic drugs containing amlodipine or candesartan

Peter Uestuener, Alessandra Ferrarini, Maristella Santi, Chiara Mardegan, Mario G. Bianchetti, Giacomo D. Simonetti, Gregorio P. Milani, Sebastiano A G Lava

Research output: Contribution to journalArticlepeer-review

Abstract

Trials with pulverized brand-name antihypertensive drugs suggest that, from the perspective of taste acceptability, crushed candesartan, chlortalidon, hydrochlorothiazide, lercanidipine and lisinopril should be preferred to pulverized amlodipine, atenolol, bisoprolol, enalapril, irbesartan, losartan, ramipril, telmisartan and valsartan. Brand-name antihypertensive drugs and the corresponding generic medicines have never been compared with respect to their taste acceptability. We therefore investigated among healthy health care workers the taste acceptability of a pulverized 1 mg-test dose of the brand-name and two generics containing either the dihydropyridine calcium-channel blocker amlodipine (Norvasc®, Amlodipin-Mepha® and Amlodipin Pfizer®) or the angiotensin receptor antagonist candesartan (Atacand®, Cansartan-Mepha® and Pemzek®). For this purpose, a smiley-face scale depicting four degrees of pleasure was used. Between November and December 2013, the taste test was performed among 19 nurses (15 female and 4 male subjects) and 12 physicians (5 female and 7 male subjects) aged between 25 and 49 years. Pulverized brand-names and generics containing either amlodipine or candesartan did not differ with respect to their taste acceptability.

Original languageEnglish
Pages (from-to)196-198
Number of pages3
JournalInternational Journal of Pharmaceutics
Volume468
Issue number1-2
DOIs
Publication statusPublished - Jul 1 2014

Keywords

  • Angiotensin receptor antagonists
  • Calcium-channel blockers
  • Hypertension
  • Medication adherence
  • Taste perception

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Medicine(all)

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