Tau protein immunolocalization in fetal and adult human spinal cord

P. Liberini, A. Valerio, G. Moretto, P. Rizzonelli, M. Memo, N. Rizzuto, P. F. Spano

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and dorsolateral funiculi, and in restricted regions of the dorsal horn. Alz-50 immunoreactivity was also demonstrated in the dorsal root ganglion neurons. In the adult spinal cord a consistent pattern of Alz-50 fiber immunoreactivity was localized in the superficial layers of the dorsal horn (lamina I and II) but not in dorsal and dorsolateral funiculi and in the dorsal root ganglion. Comparable results in fetal specimens have been obtained employing PHF-1, a monoclonal antibody generated against paired helical filament proteins from Alzheimer brains, while no significant immunostaining for PHF-1 was observed in the adult spinal cord. In addition, the staining with monoclonal and polyclonal anti-tau antibodies overlapped with that of Alz-50. The transient, selective pattern of Alz-50 and PHF-1 immunoreactivity may disclose some relevant functions of tau proteins during somatosensory pathway development.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalNeuroscience Research
Volume22
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • Alz-50 monoclonal antibody
  • Development
  • Fetus
  • Human
  • PHF-1 monoclonal antibody
  • Spinal cord
  • Tau protein

ASJC Scopus subject areas

  • Neuroscience(all)

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