Tau protein role in sleep-wake cycle

Jose L. Cantero, Eva Hita-Yaez, Bernardo Moreno-Lopez, Federico Portillo, Alicia Rubio, Jesus Avila

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Evidence has shown that the lack of tau produces subtle changes in neuronal structure and modest impairment in complex behaviors, suggesting compensatory mechanisms carried out by other neuronal microtubule-associated proteins. Here we show major abnormalities in sleep-wake cycle of tau-deficient animals including increased wakefulness duration and decreased non-rapid eye movement (NREM) sleep time, a higher number of state transitions between NREM and wake, and shortened sleep bouts. Altered sleep structure in tau-/- mice was accompanied by a significant decline in delta power together with an enhanced spectral density of sleep spindles during NREM sleep. No significant differences were observed in rapid eye movement (REM) sleep between the two mouse strains. Taken together, these results suggest that tau indirectly participates in the regulation of the sleep-wake cycle modulating not only the control and maintenance of global brain states but also the cerebral oscillatory patterns underlying sleep-wake states.

Original languageEnglish
Pages (from-to)411-421
Number of pages11
JournalJournal of Alzheimer's Disease
Volume21
Issue number2
DOIs
Publication statusPublished - 2010

Fingerprint

tau Proteins
Sleep
Eye Movements
Microtubule-Associated Proteins
Wakefulness
REM Sleep
Maintenance

Keywords

  • Animal models
  • local field potential
  • microtubule-associated proteins
  • neuronal cytoskeleton
  • sleep-wake regulation
  • state-dependent brain oscillations
  • tau

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Cantero, J. L., Hita-Yaez, E., Moreno-Lopez, B., Portillo, F., Rubio, A., & Avila, J. (2010). Tau protein role in sleep-wake cycle. Journal of Alzheimer's Disease, 21(2), 411-421. https://doi.org/10.3233/JAD-2010-100285

Tau protein role in sleep-wake cycle. / Cantero, Jose L.; Hita-Yaez, Eva; Moreno-Lopez, Bernardo; Portillo, Federico; Rubio, Alicia; Avila, Jesus.

In: Journal of Alzheimer's Disease, Vol. 21, No. 2, 2010, p. 411-421.

Research output: Contribution to journalArticle

Cantero, JL, Hita-Yaez, E, Moreno-Lopez, B, Portillo, F, Rubio, A & Avila, J 2010, 'Tau protein role in sleep-wake cycle', Journal of Alzheimer's Disease, vol. 21, no. 2, pp. 411-421. https://doi.org/10.3233/JAD-2010-100285
Cantero JL, Hita-Yaez E, Moreno-Lopez B, Portillo F, Rubio A, Avila J. Tau protein role in sleep-wake cycle. Journal of Alzheimer's Disease. 2010;21(2):411-421. https://doi.org/10.3233/JAD-2010-100285
Cantero, Jose L. ; Hita-Yaez, Eva ; Moreno-Lopez, Bernardo ; Portillo, Federico ; Rubio, Alicia ; Avila, Jesus. / Tau protein role in sleep-wake cycle. In: Journal of Alzheimer's Disease. 2010 ; Vol. 21, No. 2. pp. 411-421.
@article{9202d96399594e3d9e6d3ceb54ec7606,
title = "Tau protein role in sleep-wake cycle",
abstract = "Evidence has shown that the lack of tau produces subtle changes in neuronal structure and modest impairment in complex behaviors, suggesting compensatory mechanisms carried out by other neuronal microtubule-associated proteins. Here we show major abnormalities in sleep-wake cycle of tau-deficient animals including increased wakefulness duration and decreased non-rapid eye movement (NREM) sleep time, a higher number of state transitions between NREM and wake, and shortened sleep bouts. Altered sleep structure in tau-/- mice was accompanied by a significant decline in delta power together with an enhanced spectral density of sleep spindles during NREM sleep. No significant differences were observed in rapid eye movement (REM) sleep between the two mouse strains. Taken together, these results suggest that tau indirectly participates in the regulation of the sleep-wake cycle modulating not only the control and maintenance of global brain states but also the cerebral oscillatory patterns underlying sleep-wake states.",
keywords = "Animal models, local field potential, microtubule-associated proteins, neuronal cytoskeleton, sleep-wake regulation, state-dependent brain oscillations, tau",
author = "Cantero, {Jose L.} and Eva Hita-Yaez and Bernardo Moreno-Lopez and Federico Portillo and Alicia Rubio and Jesus Avila",
year = "2010",
doi = "10.3233/JAD-2010-100285",
language = "English",
volume = "21",
pages = "411--421",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "2",

}

TY - JOUR

T1 - Tau protein role in sleep-wake cycle

AU - Cantero, Jose L.

AU - Hita-Yaez, Eva

AU - Moreno-Lopez, Bernardo

AU - Portillo, Federico

AU - Rubio, Alicia

AU - Avila, Jesus

PY - 2010

Y1 - 2010

N2 - Evidence has shown that the lack of tau produces subtle changes in neuronal structure and modest impairment in complex behaviors, suggesting compensatory mechanisms carried out by other neuronal microtubule-associated proteins. Here we show major abnormalities in sleep-wake cycle of tau-deficient animals including increased wakefulness duration and decreased non-rapid eye movement (NREM) sleep time, a higher number of state transitions between NREM and wake, and shortened sleep bouts. Altered sleep structure in tau-/- mice was accompanied by a significant decline in delta power together with an enhanced spectral density of sleep spindles during NREM sleep. No significant differences were observed in rapid eye movement (REM) sleep between the two mouse strains. Taken together, these results suggest that tau indirectly participates in the regulation of the sleep-wake cycle modulating not only the control and maintenance of global brain states but also the cerebral oscillatory patterns underlying sleep-wake states.

AB - Evidence has shown that the lack of tau produces subtle changes in neuronal structure and modest impairment in complex behaviors, suggesting compensatory mechanisms carried out by other neuronal microtubule-associated proteins. Here we show major abnormalities in sleep-wake cycle of tau-deficient animals including increased wakefulness duration and decreased non-rapid eye movement (NREM) sleep time, a higher number of state transitions between NREM and wake, and shortened sleep bouts. Altered sleep structure in tau-/- mice was accompanied by a significant decline in delta power together with an enhanced spectral density of sleep spindles during NREM sleep. No significant differences were observed in rapid eye movement (REM) sleep between the two mouse strains. Taken together, these results suggest that tau indirectly participates in the regulation of the sleep-wake cycle modulating not only the control and maintenance of global brain states but also the cerebral oscillatory patterns underlying sleep-wake states.

KW - Animal models

KW - local field potential

KW - microtubule-associated proteins

KW - neuronal cytoskeleton

KW - sleep-wake regulation

KW - state-dependent brain oscillations

KW - tau

UR - http://www.scopus.com/inward/record.url?scp=77957552903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957552903&partnerID=8YFLogxK

U2 - 10.3233/JAD-2010-100285

DO - 10.3233/JAD-2010-100285

M3 - Article

VL - 21

SP - 411

EP - 421

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 2

ER -