Tauopathy in human and experimental variant Creutzfeldt-Jakob disease

G. Giaccone, M. Mangieri, R. Capobianco, L. Limido, J. J. Hauw, S. Haïk, P. Fociani, O. Bugiani, F. Tagliavini

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebral accumulation of hyperphosphorylated tau (phospho-tau) occurs in several neurodegenerative conditions including Alzheimer disease. In prion diseases, phospho-tau deposition has been described in a rare genetic form, Gerstmann-Sträussler-Scheinker disease, but is not considered part of the neuropathological picture of Creutzfeldt-Jakob disease. Aim of this study was to investigate whether changes related to phospho-tau accumulation are present in the brain of patients with variant Creutzfeldt-Jakob disease (vCJD) that shares with Gerstmann-Sträussler-Scheinker disease abundant prion protein (PrP) deposition in amyloid form. The analysis was extended to experimental mouse models of vCJD. We detected a large number of phospho-tau-immunoreactive neuritic profiles, often clustered around PrP amyloid deposits, not only in the cerebral cortex, but also in the cerebellum of all vCJD patients examined, in the absence of Aβ. Although less constantly, phospho-tau was localized in some perikaria and dendrites. The biochemical counterpart was the presence of phospho-tau in the detergent-insoluble fraction of cerebral cortex. Phospho-tau-immunoreactive neuronal profiles were also found in association with PrP deposits in mouse models of vCJD. These findings suggest that the abnormal forms of PrP associated with vCJD trigger a tauopathy, and provide a paradigm for the early stages of tau pathology associated with cerebral amyloidoses, including Alzheimer disease.

Original languageEnglish
Pages (from-to)1864-1873
Number of pages10
JournalNeurobiology of Aging
Volume29
Issue number12
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Alzheimer disease
  • Immunohistochemistry
  • Prion protein
  • Tau
  • Tauopathy
  • Variant Creutzfeldt-Jakob disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Tauopathy in human and experimental variant Creutzfeldt-Jakob disease'. Together they form a unique fingerprint.

Cite this