Taylor-type focal cortical dysplasia: Is the epilepsy always resistant to medical treatment?

Ennio Del Giudice, Maria Cristina Bianchi, Michela Tosetti, Andrea Varrone, Alfonso Romano, Angela Francesca Crisanti, Luigi Titomanlio, Floriana Imperati

Research output: Contribution to journalArticlepeer-review


Patients with Taylor-type focal cortical dysplasia (TTFCD) generally present with medically intractable epilepsy and impaired neurological and/or intellectual functioning. Surgery usually proves to be the only treatment approach leading to control of seizures. We describe a 17-year-old girl with TTFCD who exhibited a very long period of seizure remission. Combined clinical and neuroimaging findings were compatible with a diagnosis of a balloon cell-subtype TTFCD. As for the clinical course, partial motor seizures began at one year of age and ceased at five: our patient has had no seizure recurrence over a 12-year-follow-up. Moreover, throughout the 15-year follow-up, neurological examinations and cognitive abilities always remained within normal limits. Neuropsychological assessment clearly showed no impairments in executive functions: planning abilities, working memory, attention and impulse control, or constructive aspects of motor coordination. The predominant deficits pertained to verbal abilities in the context of borderline intellectual performances. To our knowledge, this case report documents the longest duration of seizure remission in a patient with TTFCD, thus emphasizing the possible benign course of such dysplastic lesions which usually have a poor prognosis, leading to early surgical treatment.

Original languageEnglish
Pages (from-to)289-293
Number of pages5
JournalEpileptic Disorders
Issue number4
Publication statusPublished - Dec 2006


  • Cortical dysplasia
  • Dysplastic lesion
  • Natural evolution
  • Taylor-type focal cortical dysplasia

ASJC Scopus subject areas

  • Clinical Neurology


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