TB and MDR-TB: What is new in 2012?

Marina Tadolini, Rosella Centis, Lia D'Ambrosio, Giovanni Battista Migliori

Research output: Contribution to journalArticlepeer-review


In 2007, the 125th anniversary of the discovery of Mycobacterium tuberculosis by Robert Koch followed a particularly significant year in the history of tuberculosis (TB) as, in the same year, the World Health Organization and other international organisations published a series of pillar documents and guidelines that set the pathway to improve the control of TB at the global level. Among these, we can mention the Stop TB Strategy, the guidelines on drug-resistant TB management, the Global Plan to Stop TB 2006-2015 and the International Standard of TB Care. Despite the positive results obtained with the implementation of the new recommendations, some crucial gaps remained urgent, such as the need for innovative diagnostic tools for the prompt diagnosis of TB, the rapid identification of drug-resistant strains and the development of new drugs to combat the increasing number of drug-resistant forms of TB. This year, 130 years after Robert Koch's discovery, we can recognise that some of these requests have been met. This article will describe the progresses made in different fields including: laboratory diagnosis and the experience with Xpert1 MTB/RIF assay; multi/extensively drug resistant-TB management and development of new promising drugs; implementation of TB/HIV collaborative activities.

Original languageEnglish
Pages (from-to)101-111
Number of pages11
Issue number2
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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