Tc-99m tetrofosmin tomography after nitrate administration in patients with ischemic left ventricular dysfunction: Relation to metabolic imaging by PET

Wei He, Wanda Acampa, Ciro Mainolfi, Francesco Menna, Anna Rita Sorrentino, Mario Petretta, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Background. In patients with ischemic left ventricular (LV) dysfunction, myocardial perfusion imaging after nitrate administration may improve the identification of dysfunctional but viable myocardium. This study was designed to assess the relationship between tetrofosmin uptake after nitrate administration and metabolic activity as assessed by positron emission tomography (PET) in patients with ischemic LV dysfunction. Methods and Results. Thirty-six patients with chronic myocardial infarction and LV dysfunction (ejection fraction, 35% ± 6%) underwent resting technetium 99m tetrofosmin single photon emission computed tomography (SPECT) imaging under control conditions (baseline) and after sublingual administration of 10 mg isosorbide dinitrate. Within 1 week, all patients underwent metabolic PET imaging with fluorine 18-fluorodeoxyglucose. Tetrofosmin uptake and metabolic activity were measured in 13 segments/patient. Regional LV function was assessed in corresponding segments by echocardiography. On baseline tetrofosmin imaging, 53 (40%) of the 131 akinetic or dyskinetic segments had reduced (

Original languageEnglish
Pages (from-to)599-606
Number of pages8
JournalJournal of Nuclear Cardiology
Volume10
Issue number6
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Cardiac metabolism
  • Left ventricular dysfunction
  • Nitrate
  • Tetrofosmin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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