TCGA Classification of Endometrial Cancer: the Place of Carcinosarcoma

Antonio Travaglino, Antonio Raffone, Annarita Gencarelli, Antonio Mollo, Maurizio Guida, Luigi Insabato, Angela Santoro, Gian Franco Zannoni, Fulvio Zullo

Research output: Contribution to journalReview articlepeer-review

Abstract

In 2013, The Cancer Genome Atlas (TCGA) Research Network found four novel prognostic subgroups of endometrial carcinoma: POLE/ultramutated (POLE), microsatellite-instable/hypermutated (MSI), copy-number-low/TP53-wild-type (CNL), and copy-number-highTP53-mutant (CNH). However, poor is known regarding uncommon histotypes of endometrial cancer. We aimed to assess the genetic profile of uterine carcinosarcoma (UCS) on the light of these findings. A systematic review and meta-analysis was performed through electronic databases searching (up to July 2019). All studies assessing UCS series for the TCGA classification were included. For each TCGA subgroup, pooled prevalence on the total UCS number was calculated. Four studies with 231 patients were included. Pooled prevalence of the TCGA subgroups were: 5.3% for the POLE subgroup, 7.3% for the MSI subgroup, 73.9% for the CNH subgroup, 13.5% for the CNL subgroup. The CNH subgroup predominates in UCS, while subgroups with high mutational load (POLE and MSI) are less common. UCS appears as a preferential evolution of CNH carcinomas.

Original languageEnglish
Pages (from-to)2067-2073
Number of pages7
JournalPathology and Oncology Research
Volume26
Issue number4
DOIs
Publication statusPublished - Oct 1 2020

Keywords

  • Cancer
  • Endometrium
  • Prognosis
  • PROMISE
  • Risk assessment
  • Treatment

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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