Technetium-99m sestamibi imaging in the detection of axillary lymph node involvement in patients with breast cancer

Orazio Schillaci, Francesco Scopinaro, Roberta Danieli, Rosanna Tavolaro, Pina Cannas, Valentina Picardi, Antonio Centi Colella

Research output: Contribution to journalArticle

Abstract

Background. The status of the axillary lymph nodes is the most important prognostic factor in breast cancer, and the findings of axillary node dissection remain the gold standard for the patients staging and prognosis. The aim of this study was to evaluate the usefulness of Tc-99m sestamibi scintigraphy in the detection of axillary node involvement. Materials and Methods. Forty-nine patients (age range: 32-75 years) with breast cancer were studied. Dynamic images (1-20 minutes post-injection of the radiopharmaceutical) followed by multiple planar views and tomographic images were performed. Final diagnosis was achieved by histology after surgery. Results. Metastatic axillary lymph node involvement was present in 21 patients: sensitivity was 81% (17/21) for tomographic and 61.9% (13/21) for planar images; specificity was 92.9% (26/28) and 96.4% (27/28), respectively. Conclusions. Tc-99m sestamibi imaging is a promising noninvasive method to detect axillary node metastases in patients with breast cancer; tomography appears more sensitive than planar views.

Original languageEnglish
Pages (from-to)1607-1610
Number of pages4
JournalAnticancer Research
Volume17
Issue number3 B
Publication statusPublished - 1997

Keywords

  • Axillary lymph nodes
  • Breast cancer
  • Technetium-99m sestamibi

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Schillaci, O., Scopinaro, F., Danieli, R., Tavolaro, R., Cannas, P., Picardi, V., & Colella, A. C. (1997). Technetium-99m sestamibi imaging in the detection of axillary lymph node involvement in patients with breast cancer. Anticancer Research, 17(3 B), 1607-1610.