Abstract
This study evaluated the accuracy of 99mTc SPECT in predicting restenosis after primary successful PTCA. Methods: Thirty-seven patients with equivocal symptom-limited exercise stress testing were evaluated. All patients underwent separate day exercise-rest 99mTc-sestamibi SPECT. The perfusion studies were evaluated using three different methods of analysis: visual inspection, semiquantitative and quantitative polar map analysis. The perfusion studies were interpreted in absence of a pre-PTCA scan. All patients underwent a control coronary angiography within 1 mo. Results: Sensitivity and specificity of 99mTc-sestamibi SPECT in predicting restenosis were 87.5-78%, 50-65% and 75-74% for visual inspection, semiquantitative and quantitative polar map analysis, respectively. Sensitivity and specificity related to the vascular territories were: LAD territory 93-73% (qualitative analysis), 53-60% (semiquantitative analysis), 80-67% (quantitative analysis): LCX territory 83-100% (qualitative analysis); and 33-100% (semiquantitative analysis), 67-100% (quantitative analysis); and RCA territory 67-80% (qualitative analysis), 67-60% (semiquantitative analysis), 67-80% (quantitative analysis). Conclusion: These data suggest that 99mTC-sestamibi SPECT is a useful noninvasive tool in the follow-up evaluation of patients who have undergone angiographically successful coronary angioplasty even in the absence of a pre-PTCA perfusion study.
| Original language | English |
|---|---|
| Pages (from-to) | 1300-1305 |
| Number of pages | 6 |
| Journal | Journal of Nuclear Medicine |
| Volume | 37 |
| Issue number | 8 |
| Publication status | Published - Aug 1996 |
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Keywords
- angioplasty
- restenosis
- technetium-99m-sestamibi
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty. / Milan, Elisa; Zoccarato, Orazio; Terzi, Arturo; Ettori, Federica; Leonzi, Ornella; Niccoli, Luigi; Giubbini, Raffaele.
In: Journal of Nuclear Medicine, Vol. 37, No. 8, 08.1996, p. 1300-1305.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty
AU - Milan, Elisa
AU - Zoccarato, Orazio
AU - Terzi, Arturo
AU - Ettori, Federica
AU - Leonzi, Ornella
AU - Niccoli, Luigi
AU - Giubbini, Raffaele
PY - 1996/8
Y1 - 1996/8
N2 - This study evaluated the accuracy of 99mTc SPECT in predicting restenosis after primary successful PTCA. Methods: Thirty-seven patients with equivocal symptom-limited exercise stress testing were evaluated. All patients underwent separate day exercise-rest 99mTc-sestamibi SPECT. The perfusion studies were evaluated using three different methods of analysis: visual inspection, semiquantitative and quantitative polar map analysis. The perfusion studies were interpreted in absence of a pre-PTCA scan. All patients underwent a control coronary angiography within 1 mo. Results: Sensitivity and specificity of 99mTc-sestamibi SPECT in predicting restenosis were 87.5-78%, 50-65% and 75-74% for visual inspection, semiquantitative and quantitative polar map analysis, respectively. Sensitivity and specificity related to the vascular territories were: LAD territory 93-73% (qualitative analysis), 53-60% (semiquantitative analysis), 80-67% (quantitative analysis): LCX territory 83-100% (qualitative analysis); and 33-100% (semiquantitative analysis), 67-100% (quantitative analysis); and RCA territory 67-80% (qualitative analysis), 67-60% (semiquantitative analysis), 67-80% (quantitative analysis). Conclusion: These data suggest that 99mTC-sestamibi SPECT is a useful noninvasive tool in the follow-up evaluation of patients who have undergone angiographically successful coronary angioplasty even in the absence of a pre-PTCA perfusion study.
AB - This study evaluated the accuracy of 99mTc SPECT in predicting restenosis after primary successful PTCA. Methods: Thirty-seven patients with equivocal symptom-limited exercise stress testing were evaluated. All patients underwent separate day exercise-rest 99mTc-sestamibi SPECT. The perfusion studies were evaluated using three different methods of analysis: visual inspection, semiquantitative and quantitative polar map analysis. The perfusion studies were interpreted in absence of a pre-PTCA scan. All patients underwent a control coronary angiography within 1 mo. Results: Sensitivity and specificity of 99mTc-sestamibi SPECT in predicting restenosis were 87.5-78%, 50-65% and 75-74% for visual inspection, semiquantitative and quantitative polar map analysis, respectively. Sensitivity and specificity related to the vascular territories were: LAD territory 93-73% (qualitative analysis), 53-60% (semiquantitative analysis), 80-67% (quantitative analysis): LCX territory 83-100% (qualitative analysis); and 33-100% (semiquantitative analysis), 67-100% (quantitative analysis); and RCA territory 67-80% (qualitative analysis), 67-60% (semiquantitative analysis), 67-80% (quantitative analysis). Conclusion: These data suggest that 99mTC-sestamibi SPECT is a useful noninvasive tool in the follow-up evaluation of patients who have undergone angiographically successful coronary angioplasty even in the absence of a pre-PTCA perfusion study.
KW - angioplasty
KW - restenosis
KW - technetium-99m-sestamibi
UR - http://www.scopus.com/inward/record.url?scp=0029764840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029764840&partnerID=8YFLogxK
M3 - Article
C2 - 8708760
AN - SCOPUS:0029764840
VL - 37
SP - 1300
EP - 1305
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 8
ER -