Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty

Elisa Milan, Orazio Zoccarato, Arturo Terzi, Federica Ettori, Ornella Leonzi, Luigi Niccoli, Raffaele Giubbini

Research output: Contribution to journalArticle

Abstract

This study evaluated the accuracy of 99mTc SPECT in predicting restenosis after primary successful PTCA. Methods: Thirty-seven patients with equivocal symptom-limited exercise stress testing were evaluated. All patients underwent separate day exercise-rest 99mTc-sestamibi SPECT. The perfusion studies were evaluated using three different methods of analysis: visual inspection, semiquantitative and quantitative polar map analysis. The perfusion studies were interpreted in absence of a pre-PTCA scan. All patients underwent a control coronary angiography within 1 mo. Results: Sensitivity and specificity of 99mTc-sestamibi SPECT in predicting restenosis were 87.5-78%, 50-65% and 75-74% for visual inspection, semiquantitative and quantitative polar map analysis, respectively. Sensitivity and specificity related to the vascular territories were: LAD territory 93-73% (qualitative analysis), 53-60% (semiquantitative analysis), 80-67% (quantitative analysis): LCX territory 83-100% (qualitative analysis); and 33-100% (semiquantitative analysis), 67-100% (quantitative analysis); and RCA territory 67-80% (qualitative analysis), 67-60% (semiquantitative analysis), 67-80% (quantitative analysis). Conclusion: These data suggest that 99mTC-sestamibi SPECT is a useful noninvasive tool in the follow-up evaluation of patients who have undergone angiographically successful coronary angioplasty even in the absence of a pre-PTCA perfusion study.

Original languageEnglish
Pages (from-to)1300-1305
Number of pages6
JournalJournal of Nuclear Medicine
Volume37
Issue number8
Publication statusPublished - Aug 1996

Fingerprint

Technetium Tc 99m Sestamibi
Single-Photon Emission-Computed Tomography
Angioplasty
Perfusion
Exercise
Sensitivity and Specificity
Coronary Angiography
Blood Vessels

Keywords

  • angioplasty
  • restenosis
  • technetium-99m-sestamibi

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Milan, E., Zoccarato, O., Terzi, A., Ettori, F., Leonzi, O., Niccoli, L., & Giubbini, R. (1996). Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty. Journal of Nuclear Medicine, 37(8), 1300-1305.

Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty. / Milan, Elisa; Zoccarato, Orazio; Terzi, Arturo; Ettori, Federica; Leonzi, Ornella; Niccoli, Luigi; Giubbini, Raffaele.

In: Journal of Nuclear Medicine, Vol. 37, No. 8, 08.1996, p. 1300-1305.

Research output: Contribution to journalArticle

Milan, E, Zoccarato, O, Terzi, A, Ettori, F, Leonzi, O, Niccoli, L & Giubbini, R 1996, 'Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty', Journal of Nuclear Medicine, vol. 37, no. 8, pp. 1300-1305.
Milan, Elisa ; Zoccarato, Orazio ; Terzi, Arturo ; Ettori, Federica ; Leonzi, Ornella ; Niccoli, Luigi ; Giubbini, Raffaele. / Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty. In: Journal of Nuclear Medicine. 1996 ; Vol. 37, No. 8. pp. 1300-1305.
@article{1f4c90dd5a514a87aade9030e8c3138c,
title = "Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty",
abstract = "This study evaluated the accuracy of 99mTc SPECT in predicting restenosis after primary successful PTCA. Methods: Thirty-seven patients with equivocal symptom-limited exercise stress testing were evaluated. All patients underwent separate day exercise-rest 99mTc-sestamibi SPECT. The perfusion studies were evaluated using three different methods of analysis: visual inspection, semiquantitative and quantitative polar map analysis. The perfusion studies were interpreted in absence of a pre-PTCA scan. All patients underwent a control coronary angiography within 1 mo. Results: Sensitivity and specificity of 99mTc-sestamibi SPECT in predicting restenosis were 87.5-78{\%}, 50-65{\%} and 75-74{\%} for visual inspection, semiquantitative and quantitative polar map analysis, respectively. Sensitivity and specificity related to the vascular territories were: LAD territory 93-73{\%} (qualitative analysis), 53-60{\%} (semiquantitative analysis), 80-67{\%} (quantitative analysis): LCX territory 83-100{\%} (qualitative analysis); and 33-100{\%} (semiquantitative analysis), 67-100{\%} (quantitative analysis); and RCA territory 67-80{\%} (qualitative analysis), 67-60{\%} (semiquantitative analysis), 67-80{\%} (quantitative analysis). Conclusion: These data suggest that 99mTC-sestamibi SPECT is a useful noninvasive tool in the follow-up evaluation of patients who have undergone angiographically successful coronary angioplasty even in the absence of a pre-PTCA perfusion study.",
keywords = "angioplasty, restenosis, technetium-99m-sestamibi",
author = "Elisa Milan and Orazio Zoccarato and Arturo Terzi and Federica Ettori and Ornella Leonzi and Luigi Niccoli and Raffaele Giubbini",
year = "1996",
month = "8",
language = "English",
volume = "37",
pages = "1300--1305",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "8",

}

TY - JOUR

T1 - Technetium-99m-sestamibi SPECT to detect restenosis after successful percutaneous coronary angioplasty

AU - Milan, Elisa

AU - Zoccarato, Orazio

AU - Terzi, Arturo

AU - Ettori, Federica

AU - Leonzi, Ornella

AU - Niccoli, Luigi

AU - Giubbini, Raffaele

PY - 1996/8

Y1 - 1996/8

N2 - This study evaluated the accuracy of 99mTc SPECT in predicting restenosis after primary successful PTCA. Methods: Thirty-seven patients with equivocal symptom-limited exercise stress testing were evaluated. All patients underwent separate day exercise-rest 99mTc-sestamibi SPECT. The perfusion studies were evaluated using three different methods of analysis: visual inspection, semiquantitative and quantitative polar map analysis. The perfusion studies were interpreted in absence of a pre-PTCA scan. All patients underwent a control coronary angiography within 1 mo. Results: Sensitivity and specificity of 99mTc-sestamibi SPECT in predicting restenosis were 87.5-78%, 50-65% and 75-74% for visual inspection, semiquantitative and quantitative polar map analysis, respectively. Sensitivity and specificity related to the vascular territories were: LAD territory 93-73% (qualitative analysis), 53-60% (semiquantitative analysis), 80-67% (quantitative analysis): LCX territory 83-100% (qualitative analysis); and 33-100% (semiquantitative analysis), 67-100% (quantitative analysis); and RCA territory 67-80% (qualitative analysis), 67-60% (semiquantitative analysis), 67-80% (quantitative analysis). Conclusion: These data suggest that 99mTC-sestamibi SPECT is a useful noninvasive tool in the follow-up evaluation of patients who have undergone angiographically successful coronary angioplasty even in the absence of a pre-PTCA perfusion study.

AB - This study evaluated the accuracy of 99mTc SPECT in predicting restenosis after primary successful PTCA. Methods: Thirty-seven patients with equivocal symptom-limited exercise stress testing were evaluated. All patients underwent separate day exercise-rest 99mTc-sestamibi SPECT. The perfusion studies were evaluated using three different methods of analysis: visual inspection, semiquantitative and quantitative polar map analysis. The perfusion studies were interpreted in absence of a pre-PTCA scan. All patients underwent a control coronary angiography within 1 mo. Results: Sensitivity and specificity of 99mTc-sestamibi SPECT in predicting restenosis were 87.5-78%, 50-65% and 75-74% for visual inspection, semiquantitative and quantitative polar map analysis, respectively. Sensitivity and specificity related to the vascular territories were: LAD territory 93-73% (qualitative analysis), 53-60% (semiquantitative analysis), 80-67% (quantitative analysis): LCX territory 83-100% (qualitative analysis); and 33-100% (semiquantitative analysis), 67-100% (quantitative analysis); and RCA territory 67-80% (qualitative analysis), 67-60% (semiquantitative analysis), 67-80% (quantitative analysis). Conclusion: These data suggest that 99mTC-sestamibi SPECT is a useful noninvasive tool in the follow-up evaluation of patients who have undergone angiographically successful coronary angioplasty even in the absence of a pre-PTCA perfusion study.

KW - angioplasty

KW - restenosis

KW - technetium-99m-sestamibi

UR - http://www.scopus.com/inward/record.url?scp=0029764840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029764840&partnerID=8YFLogxK

M3 - Article

C2 - 8708760

AN - SCOPUS:0029764840

VL - 37

SP - 1300

EP - 1305

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 8

ER -