Technical Note: A new zeolite PET phantom to test segmentation algorithms on heterogeneous activity distributions featured with ground-truth contours

Chiara D. Soffientini, Elisabetta De Bernardi, Rosangela Casati, Giuseppe Baselli, Felicia Zito

Research output: Contribution to journalArticle

Abstract

PURPOSE: Design, realization, scan, and characterization of a phantom for PET Automatic Segmentation (PET-AS) assessment are presented. Radioactive zeolites immersed in a radioactive heterogeneous background simulate realistic wall-less lesions with known irregular shape and known homogeneous or heterogeneous internal activity.

METHOD: Three different zeolite families were evaluated in terms of radioactive uptake homogeneity, necessary to define activity and contour ground truth. Heterogeneous lesions were simulated by the perfect matching of two portions of a broken zeolite, soaked in two different 18 F-FDG radioactive solutions. Heterogeneous backgrounds were obtained with tissue paper balls and sponge pieces immersed into radioactive solutions.

RESULTS: Natural clinoptilolite proved to be the most suitable zeolite for the construction of artificial objects mimicking homogeneous and heterogeneous uptakes in 18 F-FDG PET lesions. Heterogeneous backgrounds showed a coefficient of variation equal to 269% and 443% of a uniform radioactive solution. Assembled phantom included eight lesions with volumes ranging from 1.86 to 7.24 ml and lesion to background contrasts ranging from 4.8:1 to 21.7:1.

CONCLUSIONS: A novel phantom for the evaluation of PET-AS algorithms was developed. It is provided with both reference contours and activity ground truth, and it covers a wide range of volumes and lesion to background contrasts. The dataset is open to the community of PET-AS developers and utilizers.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalMedical Physics
Volume44
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • 18F-FDG PET
  • experimental phantoms
  • segmentation
  • zeolites

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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