Technical success, technique efficacy and complications of minimally-invasive imaging-guided percutaneous ablation procedures of breast cancer: A systematic review and meta-analysis

Giovanni Mauri, Luca Maria Sconfienza, Lorenzo Carlo Pescatori, Maria Paola Fedeli, Marco Alì, Giovanni Di Leo, Francesco Sardanelli

Research output: Contribution to journalArticle

Abstract

Objectives: To systematically review studies concerning imaging-guided minimally-invasive breast cancer treatments. Methods: An online database search was performed for English-language articles evaluating percutaneous breast cancer ablation. Pooled data and 95% confidence intervals (CIs) were calculated. Technical success, technique efficacy, minor and major complications were analysed, including ablation technique subgroup analysis and effect of tumour size on outcome. Results: Forty-five studies were analysed, including 1,156 patients and 1,168 lesions. Radiofrequency (n=577; 50%), microwaves (n=78; 7%), laser (n=227; 19%), cryoablation (n=156; 13%) and high-intensity focused ultrasound (HIFU, n=129; 11%) were used. Pooled technical success was 96% (95%CI 94–97%) [laser=98% (95–99%); HIFU=96% (90–98%); radiofrequency=96% (93–97%); cryoablation=95% (90–98%); microwave=93% (81–98%)]. Pooled technique efficacy was 75% (67–81%) [radiofrequency=82% (74–88); cryoablation=75% (51–90); laser=59% (35–79); HIFU=49% (26–74)]. Major complications pooled rate was 6% (4–8). Minor complications pooled rate was 8% (5–13%). Differences between techniques were not significant for technical success (p=0.449), major complications (p=0.181) or minor complications (p=0.762), but significant for technique efficacy (p=0.009). Tumour size did not impact on variables (p>0.142). Conclusions: Imaging-guided percutaneous ablation techniques of breast cancer have a high rate of technical success, while technique efficacy remains suboptimal. Complication rates are relatively low. Key Points: • Imaging-guided ablation techniques for breast cancer are 96% technically successful. • Overall technique efficacy rate is 75% but largely inhomogeneous among studies. • Overall major and minor complication rates are low (6–8%).

Original languageEnglish
Pages (from-to)3199-3210
Number of pages12
JournalEuropean Radiology
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

Keywords

  • Breast cancer
  • Meta-analysis
  • Minimally-invasive treatment
  • Systematic review
  • Thermal ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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