Technological platforms for microarray gene expression profiling.

Research output: Contribution to journalArticle

Abstract

By using gene microarray technology, scientists can determine in a single experiment, the expression levels of thousands of genes within a given sample. DNA microarray technology is evolving rapidly and there are now numerous high-density platforms available which differ in terms of probe content, design, deposition technology, labeling and hybridization protocols. However, two major platforms for high-density microarray manufacture are in common use. The first utilizes robotic deposition or "spotting" of DNA molecules, while the second uses short oligonucleotides synthesized in situ.

Original languageEnglish
Pages (from-to)12-18
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume593
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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