Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp.

S. Somma, L. Gastaldo, A. Corti

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Teicoplanin, a new glycopeptide antibiotic belonging to the same family as vancomycin, inhibits cell wall synthesis in Bacillus subtilis; the inhibition is accompanied by an intracellular accumulation of UDP-N-acetyl-muramyl-pentapeptide. A cell-free system from Bacillus stearothermophilus, capable of synthesizing peptidoglycan, is 50% inhibited by teicoplanin at 40 μg/ml and 100% inhibited at 100 μg/ml; suppression of peptidoglycan synthesis is accompanied by parallel accumulation of the lipid intermediate. Teicoplanin binds to cell walls and forms a complex with N,N'-diacetyl-L-lysyl-D-alanyl-D-alanine. The association constant of this complex is 2.56 x 106 liters mol-1, calculated by spectrophotometric titration. The mechanism of action of teicoplanin is discussed in comparison with those of other inhibitors of cell wall biosynthesis, namely, vancomycin, ristocetin, and gardimycin.

Original languageEnglish
Pages (from-to)917-923
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume26
Issue number6
Publication statusPublished - 1984

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Teicoplanin
Cell Wall
Anti-Bacterial Agents
Peptidoglycan
Vancomycin
Ristocetin
Geobacillus stearothermophilus
Uridine Diphosphate
Cell-Free System
Glycopeptides
Bacillus subtilis
Lipids

ASJC Scopus subject areas

  • Pharmacology (medical)

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Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. / Somma, S.; Gastaldo, L.; Corti, A.

In: Antimicrobial Agents and Chemotherapy, Vol. 26, No. 6, 1984, p. 917-923.

Research output: Contribution to journalArticle

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