Teicoplanin in the treatment of enterococcal endocarditis: Clinical and microbiological study

M. Venditti, A. Tarasi, A. Capone, M. Galié, F. Menichetti, P. Martino, P. Serra

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Seven cases of enterococcal endocarditis treated with teicoplanin (7-10 mg/kg/day for 28-105 days) alone (one case) or in combination with aminoglycosides (six cases) were reviewed. All patients were cured. Serum bactericidal activity titres after intravenous gentamicin (5 mg/kg every 24 h) and teicoplanin (10 mg/kg every 24 h) were measured on day 7 of treatment in four patients against five enterococcal isolates: mean titres were 1:54 (range 1:16-64) and 1:22 (1:8-32) at 0.5 and 24 h post-infusion, respectively. Time-kill studies showed synergy between teicoplanin and gentamicin against three isolates. We conclude that single daily-dose teicoplanin/gentamicin combined therapy may represent a rational alternative to standard penicillin/gentamicin therapy and a useful regimen for home treatment of selected cases of enterococcal endocarditis.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Issue number3
Publication statusPublished - Sep 1997

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology


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