An original thermographic method to evaluate the activity of topical corticosteroids is reported; specifically, the study has been performed employing a cream containing alclometasone dipropionate 0.1%. Eighteen healthy patients (12 women and 6 men) were studied applying the same quantity of the cream and his placebo on symmetrical areas of the upper back. In four of these, the applications were repeated twice a day for seven days. The results show that in the sides treated with alclometasone the vasoconstrictive time increases progressively with the number of the applications, from 4 hours after a single to 18 hours after 14 applications. The Authors emphasize the validity of thermography in evaluating corticosteroid to vasoconstriction as well as in establishing the correct dosage in order to avoid side effects.
|Number of pages||5|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1988|
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