Telethonin, a novel sarcomeric protein of heart and skeletal muscle

G. Valle, G. Faulkner, A. De Antoni, B. Pacchioni, A. Pallavicini, D. Pandolfo, N. Tiso, S. Toppo, S. Trevisan, G. Lanfranchi

Research output: Contribution to journalArticlepeer-review


In this paper we describe a novel 19 kDa sarcomeric protein named telethonin. The cDNA sequence discloses an open reading frame of 167 amino acids that does not resemble any known protein, Antibodies against a recombinant telethonin fragment were used for Western blot analysis, confirming the presence of this 19 kDa protein in heart and skeletal muscle and revealing an immunofluorescence pattern typical of sarcomeric proteins, overlapping myosin. The frequency of specific cDNA clones in different libraries indicates that the telethonin transcript is amongst the most abundant in skeletal muscle. In human, telethonin maps at 17q12, adjacent to the phenylethanolamine N-methyltransferase gene.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalFEBS Letters
Issue number2
Publication statusPublished - Sep 29 1997


  • Expressed sequence tag
  • Sarcomeric protein
  • Skeletal muscle

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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