Abstract
In this paper we describe a novel 19 kDa sarcomeric protein named telethonin. The cDNA sequence discloses an open reading frame of 167 amino acids that does not resemble any known protein, Antibodies against a recombinant telethonin fragment were used for Western blot analysis, confirming the presence of this 19 kDa protein in heart and skeletal muscle and revealing an immunofluorescence pattern typical of sarcomeric proteins, overlapping myosin. The frequency of specific cDNA clones in different libraries indicates that the telethonin transcript is amongst the most abundant in skeletal muscle. In human, telethonin maps at 17q12, adjacent to the phenylethanolamine N-methyltransferase gene.
| Original language | English |
|---|---|
| Pages (from-to) | 163-168 |
| Number of pages | 6 |
| Journal | FEBS Letters |
| Volume | 415 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Sep 29 1997 |
Keywords
- Expressed sequence tag
- Sarcomeric protein
- Skeletal muscle
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Cite this
Valle, G., Faulkner, G., De Antoni, A., Pacchioni, B., Pallavicini, A., Pandolfo, D., Tiso, N., Toppo, S., Trevisan, S., & Lanfranchi, G. (1997). Telethonin, a novel sarcomeric protein of heart and skeletal muscle. FEBS Letters, 415(2), 163-168. https://doi.org/10.1016/S0014-5793(97)01108-3